MUC5AC 表达升高与错配修复缺陷和近端肿瘤位置相关，但与结肠癌的癌症进展无关。

Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer.

机构信息

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

Med Mol Morphol. 2021 Jun;54(2):156-165. doi: 10.1007/s00795-020-00274-2. Epub 2020 Dec 29.

DOI:10.1007/s00795-020-00274-2

PMID:33373033

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8139930/

Abstract

Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch repair deficiency (dMMR) in colorectal cancer, a tissue microarray containing 1812 colorectal cancers was analyzed by immunohistochemistry. MUC5AC expression was found in 261 (15.7%) of 1,667 analyzable colorectal cancers. MUC5AC expression strongly depended on the tumor location and gradually decreased from proximal (27.4% of cecum cancers) to distal (10.6% of rectal cancers; p < 0.0001). MUC5AC expression was also strongly linked to dMMR. dMMR was found in 21.3% of 169 cancers with MUC5AC positivity but in only 4.6% of 1051 cancers without detectable MUC5AC expression (p < 0.0001). A multivariate analysis showed that dMMR status and tumor localization predicted MUC5AC expression independently (p < 0.0001 each). MUC5AC expression was unrelated to pT and pN status. This also applied to the subgroups of 1136 proficient MMR (pMMR) and of 84 dMMR cancers. The results of our study show a strong association of MUC5AC expression with proximal and dMMR colorectal cancers. However, MUC5AC expression is unrelated to colon cancer aggressiveness.

摘要

黏蛋白 5AC（MUC5AC）是一种由多种上皮细胞表达的分泌性凝胶形成黏蛋白。在结肠中，MUC5AC 表达于散在的正常上皮细胞中，但在结直肠癌中可能丰富。为了阐明 MUC5AC 表达与结直肠癌侵袭性参数和错配修复缺陷（dMMR）的关系，通过免疫组织化学分析了包含 1812 例结直肠癌的组织微阵列。在 1667 例可分析的结直肠癌中，发现 261 例（15.7％）表达 MUC5AC。MUC5AC 的表达强烈依赖于肿瘤位置，并从近端（盲肠癌的 27.4％）逐渐减少到远端（直肠癌的 10.6％；p<0.0001）。MUC5AC 的表达也与 dMMR 密切相关。在 169 例 MUC5AC 阳性的癌症中发现 dMMR 占 21.3％，而在 1051 例未检测到 MUC5AC 表达的癌症中仅占 4.6％（p<0.0001）。多变量分析显示，dMMR 状态和肿瘤定位独立预测 MUC5AC 表达（均 p<0.0001）。MUC5AC 表达与 pT 和 pN 状态无关。这也适用于 1136 例有功能错配修复（pMMR）和 84 例 dMMR 癌症的亚组。我们的研究结果表明，MUC5AC 表达与近端和 dMMR 结直肠癌密切相关。然而，MUC5AC 表达与结肠癌侵袭性无关。