用于预防妊娠期糖尿病的营养补充剂：基于证据的经验教训。

Suplementos nutricionales para prevención de diabetes mellitus gestacional: lecciones aprendidas basadas en la evidencia.

作者信息

Reyes-Muñoz Enrique, Sosa Salvador Espino Y, Flores-Robles Claudia M, Arce-Sánchez Lidia, Martínez-Cruz Nayeli, Gutiérrez-Castrellón Pedro

机构信息

Coordinación de Endocrinología Ginecológica y Perinatal, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes. Ciudad de México, México.

Subdirección de Investigación clínica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes. Ciudad de México, México.

出版信息

Gac Med Mex. 2020;156(Supl 3):S43-S50. doi: 10.24875/GMM.M20000437.

DOI:10.24875/GMM.M20000437

PMID:33373343

Abstract

INTRODUCTION

Gestational diabetes mellitus (GDM) affects between 5 and 40% of pregnant women. Recently different interventions with nutritional supplements have been evaluated for prevention of GDM.

AIM

To perform a synthesis of the evidence on the efficacy of nutritional supplements (myo-inositol, probiotics, and vitamin D) in the prevention of GDM.

METHODS

A systematic search in PubMed and Cochrane library was performed, including systematic reviews of randomized clinical trials (RCTs), published in English or Spanish until May 2020, using the keywords: "prevention", "gestational diabetes", "hyperglycemia and pregnancy", "supplementation", "probiotics", "myo-inositol" and "vitamin D".

RESULTS

10 systematic reviews that met the inclusion criteria were analyzed. Myo-inositol supplementation compared to placebo decreased the incidence of GDM (RR: 0.44 [0.27-0.87]; five RCTs), low quality of evidence. Although the supplementation with vitamin D or probiotics during pregnancy could reduce the incidence of GDM the evidence is limited.

CONCLUSIONS

Myo-inositol supplementation is effective for prevention of GDM in high-risk women. Supplementation with vitamin D or probiotics probably decreases the incidence of GDM.

摘要