Reyes-Muñoz Enrique, Sosa Salvador Espino Y, Flores-Robles Claudia M, Arce-Sánchez Lidia, Martínez-Cruz Nayeli, Garduño-García Guillermo, Tawney-Serrano Cesar R, Domínguez-Rodríguez Juan J, Martínez-Hernández María L, Pérez-Mota Lilia R, Llanes-Carrillo Lourdes C, González-Rodríguez Marcelo
Coordinación de Endocrinología Ginecológica y Perinatal, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México, Méx.
Subdirección de Investigación clínica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México, Méx.
Gac Med Mex. 2020;156(Supl 3):S51-S57. doi: 10.24875/GMM.M20000438.
To compare the incidence of gestational diabetes mellitus (GDM) in women with three or more risk factor to developing GDM supplemented with myo-inositol plus probiotics versus women care without supplementation.
Retrospective cohort study, group 1, women with supplementation (myo-inositol 2g plus Bifidobacterium lactis and Lactobacillus rhamnosus 5x108 UFC, twice per day, from 12-14 to 28 weeks of gestation; group 2, women with prenatal care without supplementation, matched by age and body mass index (BMI). The primary outcome was the incidence of GDM using the International Association of Diabetes and Pregnancy Study Groups criteria.
Group 1 n=48, group 2 n=96. There were no significant baseline differences between groups in age, BMI and number of risk factors. The incidence of GDM in group 1 was n=14 (29.2%), and for group 2 n=46 (47.9%); RR: 0.61 (95% CI: 0.37-0.99; p = 0.03).
Supplementation from 12-14 weeks of gestation with myo-inositol plus probiotics decrease the incidence of GDM in Mexican women.
比较有三个或更多患妊娠糖尿病（GDM）风险因素的女性补充肌醇加益生菌与未补充的女性患GDM的发生率。
回顾性队列研究，第1组为补充组（从妊娠12 - 14周到28周，每天两次，补充2克肌醇加5×10⁸CFU的乳酸双歧杆菌和鼠李糖乳杆菌）；第2组为未补充组，为接受产前护理但未补充的女性，按年龄和体重指数（BMI）匹配。主要结局是根据国际糖尿病与妊娠研究组标准确定的GDM发生率。
第1组n = 48，第2组n = 96。两组在年龄、BMI和风险因素数量方面基线无显著差异。第1组GDM发生率为n = 14（29.2%），第2组为n = 46（47.9%）；相对危险度：0.61（95%可信区间：0.37 - 0.99；p = 0.03）。
妊娠12 - 14周开始补充肌醇加益生菌可降低墨西哥女性GDM的发生率。
