Johnson T L, Lloyd R V, Thompson N W, Beierwaltes W H, Sisson J C
University of Michigan Medical Center, Ann Arbor 48109.
Am J Surg Pathol. 1988 Jan;12(1):22-7. doi: 10.1097/00000478-198801000-00003.
The tall cell variant (TCV) of papillary thyroid carcinoma, characterized by a population of tall columnar cells with a height at least twice the width, was analyzed in 12 patients and compared to tumors from 12 patients with the usual type of papillary thyroid carcinoma (UPTC) matched for age, sex, and date of diagnosis to determine if tall cell histology had prognostic significance. Patients with TCV had significantly higher incidences of extrathyroidal disease, recurrent disease, and metastases compared to patients with UPTC. TCV patients also died of their tumors more frequently than UPTC patients (3/12 versus 0/12). There was no significant difference in tumor size or in the incidence of cervical lymph node involvement between the patient groups. These results show that TCV of papillary thyroid carcinoma has a more aggressive clinical course and a worse prognosis than UPTC in patient groups with similar age and sex distribution, length of follow-up, and tumor size.
对12例甲状腺乳头状癌高细胞变体（TCV）进行了分析，其特征为一群高柱状细胞，高度至少为宽度的两倍，并与12例年龄、性别和诊断日期相匹配的普通型甲状腺乳头状癌（UPTC）患者的肿瘤进行比较，以确定高细胞组织学是否具有预后意义。与UPTC患者相比，TCV患者甲状腺外疾病、复发性疾病和转移的发生率显著更高。TCV患者死于肿瘤的频率也高于UPTC患者（3/12对0/12）。两组患者的肿瘤大小或颈部淋巴结受累发生率无显著差异。这些结果表明，在年龄和性别分布、随访时间和肿瘤大小相似的患者组中，甲状腺乳头状癌的TCV比UPTC具有更具侵袭性的临床病程和更差的预后。
