Terry J H, St John S A, Karkowski F J, Suarez J R, Yassa N H, Platica C D, Marti J R
Department of Surgery, Brooklyn Hospital Center, New York, New York 10012.
Am J Surg. 1994 Nov;168(5):459-61. doi: 10.1016/s0002-9610(05)80099-6.
The tall cell variant (TCV) of papillary thyroid cancer is reported to have a poor prognosis. This study examines the incidence and end result of surgical treatment of TCV.
In this study, 240 thyroid cancers treated over a 23-year period at two hospital centers are reviewed. A total of 153 patients with papillary cancer were available for follow-up. All microscopic slides were re-examined.
Of the total 183 papillary cancers, 19 (10.4%) were TCV. The remainder were usual papillary or other papillary cancer variants. Patient age, tumor size, lymph node and soft-tissue involvement, recurrence, and death rates were evaluated. Multivariate statistical analysis disclosed that TCV histology, as well as age and tumor size, were significant predictors of recurrence.
Despite a high rate of recurrence in TCV cases over age 50 (6/9), there were no recurrent TCVs in cases under age 50 (0/8). Pathologists and surgeons must develop an increased awareness of this entity and implications for more radical treatment in the older age group.
据报道，甲状腺乳头状癌的高细胞变体（TCV）预后较差。本研究探讨了TCV手术治疗的发生率和最终结果。
本研究回顾了在两个医院中心23年期间治疗的240例甲状腺癌。共有153例乳头状癌患者可供随访。所有显微切片均重新检查。
在总共183例乳头状癌中，19例（10.4%）为TCV。其余为普通乳头状癌或其他乳头状癌变体。评估了患者年龄、肿瘤大小、淋巴结和软组织受累情况、复发率和死亡率。多变量统计分析显示，TCV组织学以及年龄和肿瘤大小是复发的重要预测因素。
尽管50岁以上的TCV病例复发率较高（6/9），但50岁以下的病例中没有复发性TCV（0/8）。病理学家和外科医生必须提高对这一实体的认识，以及对老年组更积极治疗的影响。
