Screening Group, Section of Early Detection and Prevention, International Agency for Research on Cancer, Lyon, France.
Infections and Cancer Biology Group, Section of Infections, International Agency for Research on Cancer, Lyon, France.
PLoS One. 2020 Dec 29;15(12):e0244242. doi: 10.1371/journal.pone.0244242. eCollection 2020.
In context of the ongoing multi-centric HPV vaccine study in India, unvaccinated married women (N = 1484) aged 18-23 years were recruited in 2012-2015 as age-matched controls to the vaccinated women and followed up yearly. We assess type-specific prevalence, natural history and potential determinants of human papillomavirus (HPV) infection in these unvaccinated women. Cervical samples were collected yearly for at least four consecutive years. A Multiplex Type-Specific E7-Based polymerase chain reaction assay was used to detect 21 HPV types. HPV prevalence was 36.4% during 6 years. Most common HPV types were 16 (6.5%) and 31 (6.1%). Highest persistence were observed for HPV 35 (62.5%) and 52 (25%). New HPV acquisition rate was 5.6/1000 person-months of observation (PMO), highest for HPV 16 (1.1/1000 PMO). Type-specific clearance rates ranged between 2.9-5.5/100 PMO. HPV 16 and/or 18 infections were 41% (95% CI 4-63%) lower among women with 2-<3 years between marriage and first cervical sample collection compared to those with <2 years. HPV prevalence and acquisition rates in young Indian women were lower than their Western counterparts. HPV 16 infections being most common shows the importance and potential impact of HPV vaccination in India. Women with 2-3 years exposure had reduced risk possibly due to higher infections clearance.
在印度正在进行的多中心 HPV 疫苗研究背景下，2012-2015 年招募了未接种 HPV 疫苗的 18-23 岁已婚女性（N=1484）作为接种疫苗女性的年龄匹配对照，并进行了每年一次的随访。我们评估了这些未接种疫苗的女性中 HPV 感染的特定类型流行率、自然史和潜在决定因素。每年收集宫颈样本，至少连续收集四年。使用基于多重 E7 型特异性聚合酶链反应检测 21 种 HPV 型。6 年内 HPV 流行率为 36.4%。最常见的 HPV 类型是 16 型（6.5%）和 31 型（6.1%）。HPV 35 型（62.5%）和 52 型（25%）的持续性最高。新 HPV 感染率为 5.6/1000 人-月观察（PMO），HPV 16 型最高（1.1/1000 PMO）。特定类型的清除率在 2.9-5.5/100 PMO 之间。与首次宫颈样本采集时间<2 年的女性相比，结婚后 2-<3 年的女性 HPV 16 和/或 18 型感染率降低了 41%（95%CI 4-63%）。与西方女性相比，印度年轻女性的 HPV 流行率和感染率较低。最常见的 HPV 16 感染表明 HPV 疫苗接种在印度的重要性和潜在影响。暴露于 HPV 2-3 年的女性感染风险可能降低，这可能是由于 HPV 清除率较高。
