Laboraotry for biomolecular modelling and design, KU Leuven, Celestijnenlaan 200G, 3001 Leuven, Belgium.
Protein Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Suehiro 1-7-29, Tsurumi, Yokohama 230-0045, Japan.
Curr Opin Struct Biol. 2021 Jun;68:48-54. doi: 10.1016/j.sbi.2020.11.009. Epub 2020 Dec 27.
Many proteins are found to possess repeated structural elements, which hint at ancient evolutionary origins and ongoing evolutionary processes. β-propeller proteins are a large family of such proteins, and a popular focus of structural analysis. This review highlights recent work to understand how they arose, and how they have developed into one of the most successful of all protein folds.
许多蛋白质被发现具有重复的结构元素，这暗示了它们古老的进化起源和持续的进化过程。β-螺旋桨蛋白是这样的一大类蛋白质，也是结构分析的热门焦点。这篇综述强调了最近的研究工作，以了解它们是如何产生的，以及它们是如何发展成为所有蛋白质折叠中最成功的折叠之一的。
