Department of Psychiatry, Wakkanai City Hospital, Wakkanai, Japan; Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Psychiatry Res. 2021 Feb;296:113655. doi: 10.1016/j.psychres.2020.113655. Epub 2020 Dec 18.
The euthymic state of bipolar disorder is often characterized by impaired cognitive function. In this investigation, we hypothesized that subjective cognitive function is impaired and illness awareness is inadequate and we further explored the associations among cognitive complaints, objective cognitive functions, and current illness awareness in Japanese patients. Twenty-seven patients in remission and 27 healthy subjects were recruited in this study. The Japanese version of the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and Scale to Assess Unawareness in Mental Disorders (Japanese, SUMD-J) were used to assess each patient. All patients underwent neuropsychological tests for the assessment of objective cognitive functions. Only SUMD2.C (current awareness of the effects of medication) was significantly correlated with COBRA, and the objective cognitive assessments, Word Fluency Test and Stroop Test Reaction Time, represented significant correlations with SUMD1.C (current awareness of mental illness). In remitted bipolar outpatients, both the objective and subjective cognitive functions were found to be associated with illness awareness. However, subjective and objective cognitive functions differed in the related illness awareness subscales in fully remitted bipolar outpatients.
双相情感障碍的缓解期常伴有认知功能障碍。在本研究中，我们假设主观认知功能受损，疾病意识不足，并进一步探讨了日本患者认知主诉、客观认知功能和当前疾病意识之间的关系。本研究共招募了 27 名缓解期患者和 27 名健康对照。采用日本版认知主诉在双相障碍评定量表（COBRA）和精神障碍意识评估量表（SUMD-J）评估每位患者。所有患者均进行了神经心理学测试以评估客观认知功能。仅 SUMD2.C（当前对药物影响的意识）与 COBRA 显著相关，而客观认知评估，即词语流畅性测验和斯特鲁普测验反应时间，与 SUMD1.C（当前对精神疾病的意识）显著相关。在缓解期的双相情感障碍门诊患者中，客观和主观认知功能均与疾病意识相关。然而，在完全缓解的双相情感障碍门诊患者中，主观和客观认知功能在相关疾病意识亚量表上存在差异。
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