Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Health Care Center, Hokkaido University, Sapporo, Japan.
Psychiatry Res. 2017 Aug;254:85-89. doi: 10.1016/j.psychres.2017.04.043. Epub 2017 Apr 24.
In Japan, there are currently no reliable rating scales for the evaluation of subjective cognitive impairment in patients with bipolar disorder. We studied the relationship between the Japanese version of the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and objective cognitive assessments in patients with bipolar disorder. We further assessed the reliability and validity of the COBRA. Forty-one patients, aged 16-64, in a remission period of bipolar disorder were recruited from Hokkaido University Hospital in Sapporo, Japan. The COBRA (Japanese version) and Frankfurt Complaint Questionnaire (FCQ), the gold standard in subjective cognitive assessment, were administered. A battery of neuropsychological tests was employed to measure objective cognitive impairment. Correlations among the COBRA, FCQ, and neuropsychological tests were determined using Spearman's correlation coefficient. The Japanese version of the COBRA had high internal consistency, good retest reliability, and concurrent validity-as indicated by a strong correlation with the FCQ. A significant correlation was also observed between the COBRA and objective cognitive measurements of processing speed. These findings are the first to demonstrate that the Japanese version of the COBRA may be clinically useful as a subjective cognitive impairment rating scale in Japanese patients with bipolar disorder.
在日本，目前尚无可靠的评定量表可用于评估双相情感障碍患者的主观认知障碍。我们研究了双相情感障碍认知主诉评定量表（COBRA）日译本与双相情感障碍患者客观认知评估之间的关系。我们进一步评估了 COBRA 的信度和效度。从日本札幌北海道大学医院招募了 41 名处于缓解期的 16-64 岁双相情感障碍患者。对这些患者进行了 COBRA（日译本）和法兰克福认知主诉问卷（FCQ）评估，FCQ 是主观认知评估的金标准。采用一套神经心理学测试来衡量客观认知障碍。采用 Spearman 相关系数确定 COBRA、FCQ 和神经心理学测试之间的相关性。COBRA 日译本具有较高的内部一致性、良好的重测信度和同时效度，与 FCQ 具有很强的相关性。COBRA 与处理速度的客观认知测量之间也存在显著相关性。这些发现首次表明，COBRA 日译本可能在临床上有用，可作为日本双相情感障碍患者主观认知障碍的评定量表。
