Shin Young Joo, Kim Eunbi, Han Bobby Kwanghoon, Yi Kayoung
Department of Ophthalmology, Hallym University College of Medicine, Seoul 07441, Korea.
Eyeforest Clinic, Seoul 04701, Korea.
Diagnostics (Basel). 2020 Dec 24;11(1):20. doi: 10.3390/diagnostics11010020.
Despite the importance of the early detection of glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for glaucoma diagnosis in Korea. Forty-two volunteers with/without open-angle glaucoma were enrolled from January through October 2015-divided into a control or open-angle glaucoma group, which was further divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups-and underwent assessments for myelin basic protein (MBP), heat shock protein 60, anti-Sjögren's-syndrome-related antigen A (SSA) and antigen B (SSB), anti-α-fodrin, and anti-nucleic acid. The glaucoma group showed a higher serum MBP level and lower serum anti-α-fodrin antibody level than the control group ( < 0.05). The NTG group showed higher serum anti-SSA and anti-SSB levels and lower anti-α-fodrin IgG/IgA levels than the HTG group. In the receiver operating characteristic curve analysis, the area under the curve (AUC) for serum MBP level was 0.917 in discriminating between controls and patients with glaucoma. Between the NTG and HTG groups, anti-SSA, anti-SSB, and anti-α-fodrin IgG/IgA levels showed an AUC above 0.8. Thus, these biomarkers were useful for diagnosing glaucoma and discriminating between controls and patients with glaucoma, and patients with NTG and HTG.
尽管青光眼早期检测很重要，但大多数进行性青光眼患者症状轻微。我们旨在评估韩国青光眼诊断的生物标志物。2015年1月至10月招募了42名有/无开角型青光眼的志愿者，分为对照组或开角型青光眼组，后者又进一步分为正常眼压性青光眼（NTG）和高眼压性青光眼（HTG）组，并对髓鞘碱性蛋白（MBP）、热休克蛋白60、抗干燥综合征相关抗原A（SSA）和抗原B（SSB）、抗α-血影蛋白和抗核酸进行了评估。青光眼组血清MBP水平高于对照组，血清抗α-血影蛋白抗体水平低于对照组（<0.05）。NTG组血清抗SSA和抗SSB水平高于HTG组，抗α-血影蛋白IgG/IgA水平低于HTG组。在受试者工作特征曲线分析中，血清MBP水平在区分对照组和青光眼患者时曲线下面积（AUC）为0.917。在NTG组和HTG组之间，抗SSA、抗SSB和抗α-血影蛋白IgG/IgA水平的AUC均高于0.8。因此，这些生物标志物有助于青光眼的诊断，以及区分对照组与青光眼患者，以及NTG和HTG患者。
