Department of Ophthalmology, Johannes Kepler University Linz, Kepler University Hospital GmBh , Linz, Austria.
Curr Eye Res. 2020 Sep;45(9):1168-1172. doi: 10.1080/02713683.2020.1722178. Epub 2020 Feb 3.
The purpose of the present study was to determine if swept-source optical coherence tomography angiography (OCTA) of the superficial plexus in the macular region can detect differences between high-tension open-angle glaucoma (HTG) and normal-tension glaucoma (NTG).
In this prospective study 60 eyes from 60 patients (40 HTG; 20 NTG) underwent fovea centred 3 × 3 mm cube macula OCTA imaging by a swept-source OCTA device (Plex Elite, Zeiss, Jena, Germany). Quantitative analysis of the vasculature at the superficial plexus was performed by assessing the Perfusion Density (PD), defined as the total area of perfused vasculature per unit area in a region of measurement, for each group, respectively. Besides, macular ganglion cell layer thickness and mean deviation from visual field testing was assessed and correlated with PD.
Average superficial PD of the measured 3 × 3 mm field was comparable between HTG and NTG ( = .567). In both groups a significant relation of PD and age (HTG: r = -0.48, = .002; NTG: r = -0.615; = .004) was shown, indicating reduced PD with increasing age. For both groups a positive correlation between PD and mean deviation (MD) (HTG: r = 0.492, = .003; NTG: r = 0.530, = .029) as well as PD and GCL thickness was shown (r = 0.486, = .002 vs. r = 0.389; = .09). However, the latter did not reach statistical significance in the NTG group.
PD at the central 3 mm around the fovea is comparable between HTG and NTG. Significant correlation with age and MD was shown in both groups.
本研究旨在确定黄斑区浅层脉络膜光相干断层扫描血管造影（OCTA）是否可以检测出高压开角型青光眼（HTG）和正常眼压型青光眼（NTG）之间的差异。
在这项前瞻性研究中，60 名患者（40 名 HTG；20 名 NTG）的 60 只眼接受了基于扫频源 OCTA 设备（蔡司公司的 Plex Elite，德国耶拿）的黄斑中心 3×3mm 立方 OCTA 成像。通过评估每个组别的灌注密度（PD），对浅层脉络膜的血管进行定量分析。PD 定义为测量区域内每单位面积的灌注血管总面积。此外，评估了黄斑神经节细胞层厚度和视野测试的平均偏差，并与 PD 相关。
测量的 3×3mm 区域的平均浅层 PD 在 HTG 和 NTG 之间具有可比性（ =.567）。在两组中，PD 与年龄均呈显著相关（HTG：r = -0.48， =.002；NTG：r = -0.615； =.004），表明 PD 随年龄增加而降低。对于两组，PD 与平均偏差（MD）之间呈正相关（HTG：r = 0.492， =.003；NTG：r = 0.530， =.029）以及 PD 与 GCL 厚度之间呈正相关（r = 0.486， =.002 与 r = 0.389； =.09）。然而，在 NTG 组中，后者未达到统计学意义。
黄斑中心 3mm 范围内的 PD 在 HTG 和 NTG 之间具有可比性。在两组中均显示出与年龄和 MD 的显著相关性。
