Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy.

OBJECTIVE

To assess the impact of (low) dose irradiation to the lungs and heart on the incidence of pneumonitis and pulmonary function changes after thoracic radiotherapy (RT). Methods/Material: Data of 62 patients treated with curative thoracic radiotherapy were analyzed. Toxicity data and pulmonary function tests (PFTs) were obtained before RT and at 6 weeks, at 12 weeks, and at 6 months after RT. PFTs included ventilation (e.g., vital capacity) and diffusion parameters (e.g., diffusion capacity for carbon monoxide (DL)). Dosimetric data of the lung and heart were extracted to assess the impact of dose on PFT changes and radiation pneumonitis (RP).

RESULTS

No statistically significant correlations between dose parameters and changes in ventilation parameters were found. There were statistically significant correlations between DL and low-dose parameters of the lungs (V-V (%)) and irradiation of the heart during the follow-up up to 6 months after RT, as well as a temporary correlation of the V (%) on the blood gas parameters at 12 weeks after RT. On multivariate analysis, both heart and lung parameters had a significant impact on DL. There was no statistically significant influence of any patient or treatment-related (including dose parameters) factors on the incidence of ≥G2 pneumonitis.

CONCLUSION

There seems to be a lasting impact of low dose irradiation to the lung as well as irradiation to the heart on the DL after thoracic radiotherapy. No influence on RP was found in this analysis.