Grochowski Cezary, Jonak Kamil, Maciejewski Marcin, Stępniewski Andrzej, Rahnama-Hezavah Mansur
Laboratory of Virtual Man, Chair of Anatomy, Medical University of Lublin, 20-439 Lublin, Poland.
Department of Clinical Neuropsychiatry, Medical University of Lublin, 20-439 Lublin, Poland.
J Clin Med. 2020 Dec 23;10(1):14. doi: 10.3390/jcm10010014.
The aim of this study was to assess the volumetry of the hippocampus in the Leber's hereditary optic neuropathy (LHON) of blind patients.
A total of 25 patients with LHON were randomly included into the study from the national health database. A total of 15 patients were selected according to the inclusion criteria. The submillimeter segmentation of the hippocampus was based on three-dimensional spoiled gradient recalled acquisition in steady state (3D-SPGR) BRAVO 7T magnetic resonance imaging (MRI) protocol.
Statistical analysis revealed that compared to healthy controls (HC), LHON subjects had multiple significant differences only in the right hippocampus, including a significantly higher volume of hippocampal tail ( = 0.009), subiculum body ( = 0.018), CA1 body ( = 0.002), hippocampal fissure ( = 0.046), molecular layer hippocampus (HP) body ( = 0.014), CA3 body ( = 0.006), Granule Cell (GC) and Molecular Layer (ML) of the Dentate Gyrus (DG)-GC ML DG body ( = 0.003), CA4 body ( = 0.001), whole hippocampal body ( = 0.018), and the whole hippocampus volume ( = 0.023).
The ultra-high-field magnetic resonance imaging allowed hippocampus quality visualization and analysis, serving as a powerful in vivo diagnostic tool in the diagnostic process and LHON disease course assessment. The study confirmed previous reports regarding volumetry of hippocampus in blind individuals.
本研究旨在评估失明患者的Leber遗传性视神经病变(LHON)中海马体的体积。
从国家健康数据库中随机纳入25例LHON患者进行研究。根据纳入标准共选取15例患者。海马体的亚毫米分割基于稳态三维扰相梯度回波采集(3D-SPGR)BRAVO 7T磁共振成像(MRI)协议。
统计分析显示,与健康对照(HC)相比,LHON受试者仅在右侧海马体存在多个显著差异,包括海马尾体积显著更高(=0.009)、下托体(=0.018)、CA1体(=0.002)、海马裂(=0.046)、分子层海马体(HP)体(=0.014)、CA3体(=0.006)、齿状回颗粒细胞(GC)和分子层(ML)-GC ML DG体(=0.003)、CA4体(=0.001)、整个海马体(=0.018)以及整个海马体体积(=0.023)。
超高场磁共振成像能够实现海马体的高质量可视化和分析,在诊断过程及LHON病程评估中作为一种强大的体内诊断工具。该研究证实了先前关于盲人海马体体积的报道。