Grochowski Cezary, Jonak Kamil, Maciejewski Marcin, Stępniewski Andrzej, Rahnama-Hezavah Mansur
Laboratory of Virtual Man, Chair of Anatomy, Medical University of Lublin, 20-439 Lublin, Poland.
Department of Clinical Neuropsychiatry, Medical University of Lublin, 20-439 Lublin, Poland.
J Clin Med. 2020 Dec 23;10(1):14. doi: 10.3390/jcm10010014.
The aim of this study was to assess the volumetry of the hippocampus in the Leber's hereditary optic neuropathy (LHON) of blind patients.
A total of 25 patients with LHON were randomly included into the study from the national health database. A total of 15 patients were selected according to the inclusion criteria. The submillimeter segmentation of the hippocampus was based on three-dimensional spoiled gradient recalled acquisition in steady state (3D-SPGR) BRAVO 7T magnetic resonance imaging (MRI) protocol.
Statistical analysis revealed that compared to healthy controls (HC), LHON subjects had multiple significant differences only in the right hippocampus, including a significantly higher volume of hippocampal tail ( = 0.009), subiculum body ( = 0.018), CA1 body ( = 0.002), hippocampal fissure ( = 0.046), molecular layer hippocampus (HP) body ( = 0.014), CA3 body ( = 0.006), Granule Cell (GC) and Molecular Layer (ML) of the Dentate Gyrus (DG)-GC ML DG body ( = 0.003), CA4 body ( = 0.001), whole hippocampal body ( = 0.018), and the whole hippocampus volume ( = 0.023).
The ultra-high-field magnetic resonance imaging allowed hippocampus quality visualization and analysis, serving as a powerful in vivo diagnostic tool in the diagnostic process and LHON disease course assessment. The study confirmed previous reports regarding volumetry of hippocampus in blind individuals.
本研究旨在评估失明患者的Leber遗传性视神经病变（LHON）中海马体的体积。
从国家健康数据库中随机纳入25例LHON患者进行研究。根据纳入标准共选取15例患者。海马体的亚毫米分割基于稳态三维扰相梯度回波采集（3D-SPGR）BRAVO 7T磁共振成像（MRI）协议。
统计分析显示，与健康对照（HC）相比，LHON受试者仅在右侧海马体存在多个显著差异，包括海马尾体积显著更高（=0.009）、下托体（=0.018）、CA1体（=0.002）、海马裂（=0.046）、分子层海马体（HP）体（=0.014）、CA3体（=0.006）、齿状回颗粒细胞（GC）和分子层（ML）-GC ML DG体（=0.003）、CA4体（=0.001）、整个海马体（=0.018）以及整个海马体体积（=0.023）。
超高场磁共振成像能够实现海马体的高质量可视化和分析，在诊断过程及LHON病程评估中作为一种强大的体内诊断工具。该研究证实了先前关于盲人海马体体积的报道。
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