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LHON 病患者海马体积的改变——7 特斯拉磁共振成像研究

Alteration within the Hippocampal Volume in Patients with LHON Disease-7 Tesla MRI Study.

作者信息

Grochowski Cezary, Jonak Kamil, Maciejewski Marcin, Stępniewski Andrzej, Rahnama-Hezavah Mansur

机构信息

Laboratory of Virtual Man, Chair of Anatomy, Medical University of Lublin, 20-439 Lublin, Poland.

Department of Clinical Neuropsychiatry, Medical University of Lublin, 20-439 Lublin, Poland.

出版信息

J Clin Med. 2020 Dec 23;10(1):14. doi: 10.3390/jcm10010014.

Abstract

PURPOSE

The aim of this study was to assess the volumetry of the hippocampus in the Leber's hereditary optic neuropathy (LHON) of blind patients.

METHODS

A total of 25 patients with LHON were randomly included into the study from the national health database. A total of 15 patients were selected according to the inclusion criteria. The submillimeter segmentation of the hippocampus was based on three-dimensional spoiled gradient recalled acquisition in steady state (3D-SPGR) BRAVO 7T magnetic resonance imaging (MRI) protocol.

RESULTS

Statistical analysis revealed that compared to healthy controls (HC), LHON subjects had multiple significant differences only in the right hippocampus, including a significantly higher volume of hippocampal tail ( = 0.009), subiculum body ( = 0.018), CA1 body ( = 0.002), hippocampal fissure ( = 0.046), molecular layer hippocampus (HP) body ( = 0.014), CA3 body ( = 0.006), Granule Cell (GC) and Molecular Layer (ML) of the Dentate Gyrus (DG)-GC ML DG body ( = 0.003), CA4 body ( = 0.001), whole hippocampal body ( = 0.018), and the whole hippocampus volume ( = 0.023).

DISCUSSION

The ultra-high-field magnetic resonance imaging allowed hippocampus quality visualization and analysis, serving as a powerful in vivo diagnostic tool in the diagnostic process and LHON disease course assessment. The study confirmed previous reports regarding volumetry of hippocampus in blind individuals.

摘要

目的

本研究旨在评估失明患者的Leber遗传性视神经病变(LHON)中海马体的体积。

方法

从国家健康数据库中随机纳入25例LHON患者进行研究。根据纳入标准共选取15例患者。海马体的亚毫米分割基于稳态三维扰相梯度回波采集(3D-SPGR)BRAVO 7T磁共振成像(MRI)协议。

结果

统计分析显示,与健康对照(HC)相比,LHON受试者仅在右侧海马体存在多个显著差异,包括海马尾体积显著更高(=0.009)、下托体(=0.018)、CA1体(=0.002)、海马裂(=0.046)、分子层海马体(HP)体(=0.014)、CA3体(=0.006)、齿状回颗粒细胞(GC)和分子层(ML)-GC ML DG体(=0.003)、CA4体(=0.001)、整个海马体(=0.018)以及整个海马体体积(=0.023)。

讨论

超高场磁共振成像能够实现海马体的高质量可视化和分析,在诊断过程及LHON病程评估中作为一种强大的体内诊断工具。该研究证实了先前关于盲人海马体体积的报道。

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