Dahmani Louisa, Courcot Blandine, Near Jamie, Patel Raihaan, Amaral Robert S C, Chakravarty M Mallar, Bohbot Véronique D
Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada.
Douglas Brain Imaging Center, Department of Psychiatry, McGill University, Montreal, QC, Canada.
Front Syst Neurosci. 2020 Jan 14;13:87. doi: 10.3389/fnsys.2019.00087. eCollection 2019.
White matter pathways that surround the hippocampus comprise its afferent and efferent connections, and are therefore crucial in mediating the function of the hippocampus. We recently demonstrated a role for the hippocampus in both spatial memory and olfactory identification in humans. In the current study, we focused our attention on the fimbria-fornix white matter bundle and investigated its relationship with spatial memory and olfactory identification. We administered a virtual navigation task and an olfactory identification task to 55 young healthy adults and measured the volume of the fimbria-fornix. We found that the volume of the right fimbria-fornix and its subdivisions is correlated with both navigational learning and olfactory identification in those who use hippocampus-based spatial memory strategies, and not in those who use caudate nucleus-based navigation strategies. These results are consistent with our recent finding that spatial memory and olfaction rely on similar neural networks and structures.
环绕海马体的白质通路构成了其传入和传出连接，因此在介导海马体的功能方面至关重要。我们最近证明了海马体在人类空间记忆和嗅觉识别中的作用。在当前的研究中，我们将注意力集中在穹窿海马伞白质束上，并研究了它与空间记忆和嗅觉识别的关系。我们对55名年轻健康成年人进行了虚拟导航任务和嗅觉识别任务，并测量了穹窿海马伞的体积。我们发现，在使用基于海马体的空间记忆策略的人群中，右侧穹窿海马伞及其分支的体积与导航学习和嗅觉识别均相关，而在使用基于尾状核的导航策略的人群中则不然。这些结果与我们最近的发现一致，即空间记忆和嗅觉依赖于相似的神经网络和结构。
