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用于脊柱固定的可吸收聚乙醇酸-聚乳酸嵌段共聚物复合材料的体外和体内生物安全性分析

In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation.

作者信息

Yoon Seung Kyun, Yang Jin Ho, Lim Hyun Tae, Chang Young-Wook, Ayyoob Muhammad, Yang Xin, Kim Young Jun, Ko Han-Seung, Jho Jae Young, Chung Dong June

机构信息

School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi 16419, Korea.

Department of Materials & Chemical Engineering, Hanyang University, 55 Hanyangdaehak-Ro, Sangnok-Gu, Ansan, Gyeonggi 15588, Korea.

出版信息

Polymers (Basel). 2020 Dec 23;13(1):29. doi: 10.3390/polym13010029.

DOI:10.3390/polym13010029
PMID:33374878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7794712/
Abstract

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA-PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

摘要

在此，使用可降解聚合物材料如聚乙醇酸-聚乳酸嵌段共聚物（聚（乙醇酸-b-乳酸））构建脊柱固定植入物。在通过体外（MTT 试验）和体内动物实验（即皮肤致敏、皮内皮内反应和体内降解试验）测试以确认其生物相容性之前，这些材料通过与羟基磷灰石接枝聚乳酸（HA-g-PLA）和聚乙醇酸纤维共混进行增强。每个标本都表现出适合用作可吸收脊柱固定材料的生物相容性和生物降解性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/cf50387747b9/polymers-13-00029-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/75355b81538b/polymers-13-00029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/573d07c7547a/polymers-13-00029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/716babfeb3db/polymers-13-00029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/adfef871a4d4/polymers-13-00029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/a5b63cfa7fbf/polymers-13-00029-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/78dd63db851e/polymers-13-00029-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/2ff4ac183b4b/polymers-13-00029-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/4954573084ea/polymers-13-00029-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/7918979e9d66/polymers-13-00029-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/37242d2fe2a6/polymers-13-00029-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/cf50387747b9/polymers-13-00029-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/75355b81538b/polymers-13-00029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/573d07c7547a/polymers-13-00029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/716babfeb3db/polymers-13-00029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/adfef871a4d4/polymers-13-00029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/a5b63cfa7fbf/polymers-13-00029-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/78dd63db851e/polymers-13-00029-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/2ff4ac183b4b/polymers-13-00029-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/4954573084ea/polymers-13-00029-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/7918979e9d66/polymers-13-00029-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/37242d2fe2a6/polymers-13-00029-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b161/7794712/cf50387747b9/polymers-13-00029-g011.jpg

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