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聚乙醇酸-聚乳酸嵌段共聚物的体内降解研究及其在脊柱固定应用中的组织化学分析

In Vivo Degradation Studies of PGA-PLA Block Copolymer and Their Histochemical Analysis for Spinal-Fixing Application.

作者信息

Yoon Seung-Kyun, Chung Dong-June

机构信息

School of Chemical Engineering, SungKyunKwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon-Si 16419, Gyeonggi-Do, Korea.

出版信息

Polymers (Basel). 2022 Aug 16;14(16):3322. doi: 10.3390/polym14163322.

DOI:10.3390/polym14163322
PMID:36015579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9415336/
Abstract

Polylactic acid (PLA) and polyglycolic acid (PGA) are well-known medical-implant materials. Under the consideration of the limitations of degradable polymeric materials, such as weak mechanical strength and by-product release through the biodegradation process under in vivo environments, PLA-PGA block copolymer is one of the effective alternative implant materials in the clinical field. In our previous study, two types of extremely effective PGA-PLA copolymers (multi/tri-block PGA-PLA copolymers) were synthesized. These synthesized block copolymers could overcome aforementioned issues and also showed good biocompatibility. In this study, the PGA-PLA block copolymers with large molecular weight were synthesized under the same chemical scheme, and their bio durability was confirmed through the in vivo degradation behavior and histochemical analyses (by hematoxylin and eosin and immune staining) in comparison with commercial PLGA random copolymer (medical grade). Specimens for the degradation test were investigated by SEM and X-ray diffractometer (XRD). As a result, the synthesized PGA-PLA block copolymer showed good biocompatibility and had a controlled biodegrading rate, making it suitable for use in resorbable spinal-fixation materials.

摘要

聚乳酸（PLA）和聚乙醇酸（PGA）是著名的医用植入材料。鉴于可降解聚合物材料存在诸如机械强度弱以及在体内环境下通过生物降解过程释放副产物等局限性，PLA - PGA嵌段共聚物是临床领域中一种有效的替代植入材料。在我们之前的研究中，合成了两种极其有效的PGA - PLA共聚物（多/三嵌段PGA - PLA共聚物）。这些合成的嵌段共聚物能够克服上述问题，并且还表现出良好的生物相容性。在本研究中，按照相同的化学方案合成了大分子量的PGA - PLA嵌段共聚物，并通过体内降解行为和组织化学分析（苏木精和伊红染色以及免疫染色）与商用PLGA无规共聚物（医用级）进行比较，证实了它们的生物耐久性。通过扫描电子显微镜（SEM）和X射线衍射仪（XRD）对降解试验的样品进行了研究。结果表明，合成的PGA - PLA嵌段共聚物具有良好的生物相容性，并且具有可控的生物降解速率，使其适用于可吸收的脊柱固定材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/d69caae6ce4d/polymers-14-03322-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/c886fca2d461/polymers-14-03322-g0A1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/0969057e7b10/polymers-14-03322-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/83238bc17c4e/polymers-14-03322-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/33ac9215b9db/polymers-14-03322-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/b8e5f2d50b18/polymers-14-03322-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/fb796ac438d0/polymers-14-03322-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/574ada9bf001/polymers-14-03322-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/912da66c7782/polymers-14-03322-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/d69caae6ce4d/polymers-14-03322-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/c886fca2d461/polymers-14-03322-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/0cc70e1b2157/polymers-14-03322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/c30755c7a84b/polymers-14-03322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/f87968a7743c/polymers-14-03322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/bf27a276a600/polymers-14-03322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/c12b4d27f468/polymers-14-03322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/0969057e7b10/polymers-14-03322-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/83238bc17c4e/polymers-14-03322-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/33ac9215b9db/polymers-14-03322-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/b8e5f2d50b18/polymers-14-03322-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/fb796ac438d0/polymers-14-03322-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/574ada9bf001/polymers-14-03322-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/912da66c7782/polymers-14-03322-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b48/9415336/d69caae6ce4d/polymers-14-03322-g013.jpg

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