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前列腺癌的分子磁共振成像

Molecular MR Imaging of Prostate Cancer.

作者信息

Kader Avan, Brangsch Julia, Kaufmann Jan O, Zhao Jing, Mangarova Dilyana B, Moeckel Jana, Adams Lisa C, Sack Ingolf, Taupitz Matthias, Hamm Bernd, Makowski Marcus R

机构信息

Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.

Department of Biology, Chemistry and Pharmacy, Institute of Biology, Freie Universität Berlin, Königin-Luise-Str. 1-3, 14195 Berlin, Germany.

出版信息

Biomedicines. 2020 Dec 22;9(1):1. doi: 10.3390/biomedicines9010001.

DOI:10.3390/biomedicines9010001
PMID:33375045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7822017/
Abstract

This review summarizes recent developments regarding molecular imaging markers for magnetic resonance imaging (MRI) of prostate cancer (PCa). Currently, the clinical standard includes MR imaging using unspecific gadolinium-based contrast agents. Specific molecular probes for the diagnosis of PCa could improve the molecular characterization of the tumor in a non-invasive examination. Furthermore, molecular probes could enable targeted therapies to suppress tumor growth or reduce the tumor size.

摘要

本综述总结了前列腺癌（PCa）磁共振成像（MRI）分子成像标记物的最新进展。目前，临床标准包括使用非特异性钆基造影剂的磁共振成像。用于PCa诊断的特异性分子探针可以在非侵入性检查中改善肿瘤的分子特征。此外，分子探针可以实现靶向治疗，以抑制肿瘤生长或减小肿瘤大小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/7954949c8c23/biomedicines-09-00001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/940ed1232efb/biomedicines-09-00001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/7f48bcb34176/biomedicines-09-00001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/1e9f5435d221/biomedicines-09-00001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/0347ed239f8d/biomedicines-09-00001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/7e06c0aecdad/biomedicines-09-00001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/7954949c8c23/biomedicines-09-00001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/940ed1232efb/biomedicines-09-00001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/7f48bcb34176/biomedicines-09-00001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/1e9f5435d221/biomedicines-09-00001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/0347ed239f8d/biomedicines-09-00001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/7e06c0aecdad/biomedicines-09-00001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a90/7822017/7954949c8c23/biomedicines-09-00001-g006.jpg

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Insights Imaging. 2020 Dec 17;11(1):137. doi: 10.1186/s13244-020-00926-y.
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Correlation between Intraprostatic PSMA Uptake and MRI PI-RADS of [Ga]Ga-PSMA-11 PET/MRI in Patients with Prostate Cancer: Comparison of PI-RADS Version 2.0 and PI-RADS Version 2.1.前列腺癌患者中[镓]镓-PSMA-11 PET/MRI的前列腺内PSMA摄取与MRI PI-RADS的相关性：PI-RADS第2.0版与PI-RADS第2.1版的比较
Cancers (Basel). 2020 Nov 26;12(12):3523. doi: 10.3390/cancers12123523.
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同时进行[镓]Ga-PSMA-11 PET/MRI的前列腺病变的动态对比增强MRI：前列腺内病变之间的比较及灌注参数的相关性
Cancers (Basel). 2021 Mar 19;13(6):1404. doi: 10.3390/cancers13061404.
The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer.
前列腺癌中 PSCA 表达与神经内分泌分化的相关性。
Biomed Res Int. 2020 Sep 24;2020:5395312. doi: 10.1155/2020/5395312. eCollection 2020.
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The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis.癌症相关成纤维细胞在前列腺癌肿瘤发生中的作用。
Cancers (Basel). 2020 Jul 13;12(7):1887. doi: 10.3390/cancers12071887.
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In Vivo Quantification of Water Diffusion, Stiffness, and Tissue Fluidity in Benign Prostatic Hyperplasia and Prostate Cancer.良性前列腺增生和前列腺癌中水扩散、硬度和组织流动性的体内定量分析。
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Aberrant KIF20A Expression Is Associated with Adverse Clinical Outcome and Promotes Tumor Progression in Prostate Cancer.异常的 KIF20A 表达与前列腺癌不良临床结局相关，并促进肿瘤进展。
Dis Markers. 2019 Sep 3;2019:4782730. doi: 10.1155/2019/4782730. eCollection 2019.
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Systemic Inflammatory Response in Predicting Prostate Cancer: The Diagnostic Value of Neutrophil-To-Lymphocyte Ratio.全身炎症反应在预测前列腺癌中的作用：中性粒细胞与淋巴细胞比值的诊断价值
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