Zhao Jing, Kader Avan, Mangarova Dilyana B, Brangsch Julia, Brenner Winfried, Hamm Bernd, Makowski Marcus R
Institute of Radiology and Nuclear Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.
Department of Biology, Chemistry and Pharmacy, Institute of Biology, Freie Universität Berlin, Königin-Luise-Str. 1-3, 14195 Berlin, Germany.
Cancers (Basel). 2021 Mar 19;13(6):1404. doi: 10.3390/cancers13061404.
We aimed to retrospectively compare the perfusion parameters measured from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) of prostate benign lesions and malignant lesions to determine the relationship between perfusion parameters. DCE-MRI was performed in patients with PCa who underwent simultaneous [Ga]Ga-prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/MRI. Six perfusion parameters (arrival time (AT), time to peak (TTP), wash-in slope (W-in), wash-out slope (W-out), peak enhancement intensity (PEI), and initial area under the 60-s curve (iAUC)), and a semi-quantitative parameter, standardized uptake values maximum (SUVmax) were calculated by placing regions of interest in the largest area of the lesions. The DCE-MRI parameters between prostate benign and malignant lesions were compared. The DCE-MRI parameters in both the benign and malignant lesions subgroup with SUVmax ≤ 3.0 and SUVmax > 3.0 were compared. The correlation of DCE-MRI parameters was investigated. Malignant lesions demonstrated significantly shorter TTP and higher SUVmax than did benign lesions. In the benign and malignant lesions subgroup, perfusion parameters of lesions with SUVmax ≤ 3.0 show no significant difference to those with SUVmax > 3.0. DCE-MRI perfusion parameters show a close correlation with each other. DCE-MRI parameters reflect the perfusion characteristics of intraprostatic lesions with malignant lesions, demonstrating significantly shorter TTP. There is a moderate to strong correlation between DCE-MRI parameters. Semi-quantitative analysis reflects that malignant lesions show a significantly higher SUVmax than benign lesions.
我们旨在回顾性比较前列腺良性病变和恶性病变的动态对比增强（DCE）磁共振成像（MRI）测量的灌注参数，以确定灌注参数之间的关系。对同时接受[镓]镓-前列腺特异性膜抗原（PSMA）-11正电子发射断层扫描（PET）/MRI的前列腺癌患者进行DCE-MRI检查。通过在病变最大区域放置感兴趣区，计算六个灌注参数（达峰时间（AT）、峰值时间（TTP）、流入斜率（W-in）、流出斜率（W-out）、峰值增强强度（PEI）和60秒曲线下初始面积（iAUC））以及一个半定量参数——最大标准化摄取值（SUVmax）。比较前列腺良性和恶性病变之间的DCE-MRI参数。比较SUVmax≤3.0和SUVmax>3.0的良性和恶性病变亚组中的DCE-MRI参数。研究DCE-MRI参数的相关性。恶性病变的TTP明显短于良性病变，SUVmax高于良性病变。在良性和恶性病变亚组中，SUVmax≤3.0的病变灌注参数与SUVmax>3.0的病变灌注参数无显著差异。DCE-MRI灌注参数之间密切相关。DCE-MRI参数反映前列腺内恶性病变的灌注特征，其TTP明显较短。DCE-MRI参数之间存在中度至高度相关性。半定量分析表明，恶性病变的SUVmax明显高于良性病变。
