• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Recent Trends in Enzyme Inhibition and Activation in Drug Design.近年来药物设计中酶抑制和激活的趋势。
Molecules. 2020 Dec 22;26(1):17. doi: 10.3390/molecules26010017.
2
Emerging trends in enzyme inhibition by multivalent nanoconstructs.多价纳米结构酶抑制的新趋势
Org Biomol Chem. 2015 Oct 21;13(39):9894-906. doi: 10.1039/c5ob01405k.
3
Drug discovery for enzymes.酶的药物发现。
Drug Discov Today. 2021 Apr;26(4):875-886. doi: 10.1016/j.drudis.2021.01.006. Epub 2021 Jan 14.
4
Advancing the kinase field: new targets and second generation inhibitors.推动激酶领域发展：新靶点与第二代抑制剂
J Med Chem. 2015 Jan 8;58(1):1. doi: 10.1021/jm5018708. Epub 2014 Dec 9.
5
Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.用于治疗糖尿病、肥胖症和癌症的竞争性蛋白酪氨酸磷酸酶1B抑制剂的最新发现进展。
J Med Chem. 2010 Mar 25;53(6):2333-44. doi: 10.1021/jm901090b.
6
Trends in Enzyme Inhibition and Activation in Drug Design - Part II.药物设计中酶抑制与激活的趋势 - 第二部分。
Curr Top Med Chem. 2019;19(5):317-318. doi: 10.2174/156802661905190418152713.
7
Advances in the computational development of DNA methyltransferase inhibitors.DNA 甲基转移酶抑制剂的计算开发进展。
Drug Discov Today. 2011 May;16(9-10):418-25. doi: 10.1016/j.drudis.2011.02.003. Epub 2011 Feb 16.
8
Current Trends in Enzyme Inhibition and Docking Analysis in Drug Design-Part -II.药物设计中酶抑制与对接分析的当前趋势 - 第二部分
Curr Top Med Chem. 2020;20(29):2649-2650. doi: 10.2174/156802662029201103090350.
9
Concepts and Core Principles of Fragment-Based Drug Design.基于片段的药物设计的概念和核心原则。
Molecules. 2019 Nov 26;24(23):4309. doi: 10.3390/molecules24234309.
10
Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story.用于治疗阿尔茨海默病的 BACE 抑制剂：基于片段的药物发现故事。
Curr Opin Chem Biol. 2013 Jun;17(3):320-8. doi: 10.1016/j.cbpa.2013.04.016. Epub 2013 May 14.

引用本文的文献

1
A Multi-Analytical Exploration of Flavored Black Teas: Profiling Volatile Compounds, Caffeine Content, and Biological Effects.调味红茶的多分析探索：挥发性化合物剖析、咖啡因含量及生物学效应
Food Sci Nutr. 2025 Jul 9;13(7):e70585. doi: 10.1002/fsn3.70585. eCollection 2025 Jul.
2
Evaluation of HPLC Profile, Antioxidant, Quorum Sensing, Biofilm, Swarming Motility, and Enzyme Inhibition Activities of Conventional and Green Extracts of ..的传统提取物和绿色提取物的高效液相色谱图谱、抗氧化、群体感应、生物膜、群游运动及酶抑制活性评估
Food Sci Nutr. 2024 Nov 24;12(12):10716-10733. doi: 10.1002/fsn3.4580. eCollection 2024 Dec.
3
Assessment of Chemical Composition and In Vitro Antioxidant, Antidiabetic, Anticholinesterase and Microbial Virulence-Quenching Effects of Salad Burnet ( L.) Harvested from Algeria.对采自阿尔及利亚的地榆（Sanguisorba minor (L.)）的化学成分、体外抗氧化、抗糖尿病、抗胆碱酯酶及微生物毒力淬灭作用的评估。
Plants (Basel). 2023 Dec 11;12(24):4134. doi: 10.3390/plants12244134.
4
Deciphering Molecular Aspects of Potential -Glucosidase Inhibitors within : A Computational Odyssey of Molecular Docking-Coupled Dynamics Simulations and Pharmacokinetic Profiling.解析潜在α-葡萄糖苷酶抑制剂的分子层面：分子对接耦合动力学模拟与药代动力学分析的计算历程
Metabolites. 2023 Aug 12;13(8):942. doi: 10.3390/metabo13080942.
5
and Evaluation of Anticholinesterase and Antidiabetic Effects of Furanolabdanes and Other Constituents from (Linn.) Griffith.呋喃甾体烷和其他成分的抗胆碱酯酶和抗糖尿病作用的评价。
Molecules. 2023 Jun 16;28(12):4802. doi: 10.3390/molecules28124802.
6
Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases.苯磺酰胺类包含海因环结构的化合物可有效抑制真核生物和人源碳酸酐酶。
Int J Mol Sci. 2022 Nov 15;23(22):14115. doi: 10.3390/ijms232214115.

本文引用的文献

1
Inside Perspective of the Synthetic and Computational Toolbox of JAK Inhibitors: Recent Updates.JAK 抑制剂的综合和计算工具包的内部视角：最新进展。
Molecules. 2020 Jul 22;25(15):3321. doi: 10.3390/molecules25153321.
2
Discovery of Novel Tankyrase Inhibitors through Molecular Docking-Based Virtual Screening and Molecular Dynamics Simulation Studies.通过基于分子对接的虚拟筛选和分子动力学模拟研究发现新型 Tankyrase 抑制剂。
Molecules. 2020 Jul 11;25(14):3171. doi: 10.3390/molecules25143171.
3
Data and Text Mining Help Identify Key Proteins Involved in the Molecular Mechanisms Shared by SARS-CoV-2 and HIV-1.数据和文本挖掘有助于确定 SARS-CoV-2 和 HIV-1 分子机制中共同涉及的关键蛋白。
Molecules. 2020 Jun 26;25(12):2944. doi: 10.3390/molecules25122944.
4
Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities.白杨素酮，一种胸苷酸合成酶抑制剂，具有杀线虫和杀肿瘤活性。
Molecules. 2020 Jun 23;25(12):2894. doi: 10.3390/molecules25122894.
5
1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors.1-(1-芳基乙基哌啶-4-基)胸腺嘧啶类似物作为抗分枝杆菌 TMPK 抑制剂。
Molecules. 2020 Jun 17;25(12):2805. doi: 10.3390/molecules25122805.
6
The Off-Target Effects, Electrolyte and Mineral Disorders of SGLT2i.SGLT2i 的脱靶效应、电解质和矿物质紊乱。
Molecules. 2020 Jun 15;25(12):2757. doi: 10.3390/molecules25122757.
7
In Silico Evaluation of the Effectivity of Approved Protease Inhibitors against the Main Protease of the Novel SARS-CoV-2 Virus.新型 SARS-CoV-2 病毒主要蛋白酶的批准蛋白酶抑制剂的有效性的计算机评估。
Molecules. 2020 May 29;25(11):2529. doi: 10.3390/molecules25112529.
8
Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-]Quinolin-2(1)-one as New Inhibitors of Factor Xa and Factor XIa.吡咯并[3,2,1-]喹啉-2(1H)-酮类杂合衍生物的合成、对接及体外抗凝血活性研究作为新型因子 Xa 和因子 XIa 抑制剂。
Molecules. 2020 Apr 19;25(8):1889. doi: 10.3390/molecules25081889.
9
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication.2-(芳基氨基)-6-(三氟甲基)烟酸衍生物：新型 HIV-1 RT 双重抑制剂，对病毒复制具有活性。
Molecules. 2020 Mar 15;25(6):1338. doi: 10.3390/molecules25061338.
10
1,2,4-Triazolo[1,5-]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.1,2,4-三唑并[1,5-a]嘧啶类作为新型 HIV-1 逆转录酶相关核糖核酸酶 H 活性抑制剂。
Molecules. 2020 Mar 5;25(5):1183. doi: 10.3390/molecules25051183.

近年来药物设计中酶抑制和激活的趋势。

Recent Trends in Enzyme Inhibition and Activation in Drug Design.

机构信息

Department of Medicinal Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

出版信息

Molecules. 2020 Dec 22;26(1):17. doi: 10.3390/molecules26010017.

DOI:10.3390/molecules26010017
PMID:33375159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7792938/
Abstract

It is known that enzymes are involved in many pathological conditions, such as inflammation, diabetes, microbial infections, HIV, neoplastic, neglected diseases and others [...].

摘要

已知酶参与许多病理状况，如炎症、糖尿病、微生物感染、HIV、肿瘤、被忽视的疾病等[... ]。