Department for Bioinformatics, Institute of Biomedical Chemistry, 107076 Moscow, Russia.
Department of Bioinformatics of Pirogov Russian National Research Medical University, 107076 Moscow, Russia.
Molecules. 2020 Jun 26;25(12):2944. doi: 10.3390/molecules25122944.
Viruses can be spread from one person to another; therefore, they may cause disorders in many people, sometimes leading to epidemics and even pandemics. New, previously unstudied viruses and some specific mutant or recombinant variants of known viruses constantly appear. An example is a variant of coronaviruses (CoV) causing severe acute respiratory syndrome (SARS), named SARS-CoV-2. Some antiviral drugs, such as remdesivir as well as antiretroviral drugs including darunavir, lopinavir, and ritonavir are suggested to be effective in treating disorders caused by SARS-CoV-2. There are data on the utilization of antiretroviral drugs against SARS-CoV-2. Since there are many studies aimed at the identification of the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) infection and the development of novel therapeutic approaches against HIV-1, we used HIV-1 for our case study to identify possible molecular pathways shared by SARS-CoV-2 and HIV-1. We applied a text and data mining workflow and identified a list of 46 targets, which can be essential for the development of infections caused by SARS-CoV-2 and HIV-1. We show that SARS-CoV-2 and HIV-1 share some molecular pathways involved in inflammation, immune response, cell cycle regulation.
病毒可以在人与人之间传播；因此，它们可能会导致许多人出现疾病，有时甚至会引发流行病和大流行。新的、以前未研究过的病毒以及某些已知病毒的特定突变体或重组变体不断出现。例如，引起严重急性呼吸系统综合症（SARS）的冠状病毒（CoV）的变体，称为 SARS-CoV-2。一些抗病毒药物，如瑞德西韦以及抗逆转录病毒药物，包括达芦那韦、洛匹那韦和利托那韦，被认为对治疗由 SARS-CoV-2 引起的疾病有效。已经有关于利用抗逆转录病毒药物治疗 SARS-CoV-2 的数据。由于有许多研究旨在确定人类免疫缺陷病毒 1 型（HIV-1）感染的分子机制并开发针对 HIV-1 的新治疗方法，我们使用 HIV-1 作为案例研究，以确定 SARS-CoV-2 和 HIV-1 之间可能存在的共同分子途径。我们应用了文本和数据挖掘工作流程，确定了 46 个可能对 SARS-CoV-2 和 HIV-1 感染的发展至关重要的靶点列表。我们表明，SARS-CoV-2 和 HIV-1 共享一些涉及炎症、免疫反应和细胞周期调节的分子途径。
