Norris P G, Murphy G M, Hawk J L, Winkelmann R K
Department of Photobiology, Mayo Clinic, Rochester, Minn.
Arch Dermatol. 1988 Jan;124(1):80-3.
The histological evolution of solar simulator-induced lesions of solar urticaria was investigated in four severely affected white patients. A series of two to 32 minimal whealing doses of radiation, each much lower than the 24-hour minimal erythema dose, was administered to separate buttock sites. Biopsy specimens were obtained from the exposed areas at five minutes and two and 24 hours later, as well as from adjacent nonexposed skin. Lesions showed a statistically significant dose-dependent increase, predominantly perivascular, in upper dermal neutrophil and eosinophil numbers at five minutes and two hours, but not at 24 hours, and at higher radiation doses in mononuclear cell numbers by 24 hours. Nonirradiated patient skin and irradiated control subject skin was not similarly affected. These changes may be associated with the pathogenesis of solar urticaria.
对四名严重受累的白人患者进行了研究，以探究太阳模拟器诱发的日光性荨麻疹皮损的组织学演变。在患者的双侧臀部不同部位给予一系列2至32个最小风团形成剂量的辐射，每个剂量均远低于24小时最小红斑剂量。分别在照射后5分钟、2小时和24小时从暴露部位以及相邻的未暴露皮肤获取活检标本。皮损显示，在5分钟和2小时时，真皮上层中性粒细胞和嗜酸性粒细胞数量呈剂量依赖性显著增加，主要为血管周围性增加，但在24小时时未出现这种情况；在24小时时，较高辐射剂量下单核细胞数量增加。未照射患者的皮肤和照射对照受试者的皮肤未出现类似变化。这些变化可能与日光性荨麻疹的发病机制有关。
