Department of Cardiologic, Vascular, and Thoracic Sciences, and Public Health, University of Padua, Padova, Italy.
Controllo di Gestione, AULSS 6 Euganea, Regione Veneto, Padova, Italy.
Int J Chron Obstruct Pulmon Dis. 2020 Dec 18;15:3357-3366. doi: 10.2147/COPD.S275687. eCollection 2020.
The worldwide prevalence of obstructive lung disease (OLD) is increasing, especially among people >65 years old, and nearly three in four adults with OLD have two or more comorbid conditions. This study describes the impact of such comorbidities on the healthcare service usage and related costs in a country with universal health coverage, basing on a large cohort of elderly patients with OLD and employing real-world data.
We carried out a retrospective cohort study on a large population of elderly (age >64 years) patients with OLD served by a Local Health Unit in northern Italy. Their comorbidities were assessed using the clinical diagnoses assigned by the Adjusted Clinical Group (ACG) system to individual patients by combining different information flows. Correlations between number of comorbidities and total annual healthcare service usage and costs were examined with Spearman's test. Regression models were applied to analyze the associations between the above-mentioned variables, adjusting for age and sex.
All types of healthcare service usage (access to emergency care; number of outpatient visits; number of hospital admissions) and pharmacy costs increased significantly with the number of comorbidities. Average total annual costs increased steadily with the number of comorbidities, ranging from € 1158.84 with no comorbidities up to € 9666.60 with 6 comorbidities or more. Poisson regression analyses showed an independent association between the number of comorbidities and the use of every type of healthcare service.
These results based on real-world data provide evidence that the burden of care for OLD patients related to their comorbidities is independent of and in addition to the burden related to OLD alone and is strongly dependent on the number of comorbidities, suggesting a holistic approach to multimorbid patients with OLD is the most sound public health strategy.
阻塞性肺疾病(OLD)在全球的患病率正在上升,尤其是在 65 岁以上人群中,近四分之三的 OLD 患者合并两种或两种以上合并症。本研究基于意大利北部一个大型老年 OLD 患者队列,利用真实世界数据,描述了这些合并症对医疗保健服务利用和相关费用的影响。
我们对意大利北部一个地方卫生单位服务的大量老年(年龄>64 岁)OLD 患者进行了回顾性队列研究。使用调整后的临床分组(ACG)系统根据不同信息来源将临床诊断分配给个体患者,评估其合并症。采用 Spearman 检验评估合并症数量与总年度医疗保健服务利用和费用之间的相关性。应用回归模型分析上述变量之间的关联,调整年龄和性别因素。
所有类型的医疗保健服务利用(急诊就诊;门诊就诊次数;住院次数)和药房费用均随合并症数量的增加而显著增加。平均年总费用随合并症数量的增加而稳步增加,从无合并症的 1158.84 欧元增加到有 6 种或更多合并症的 9666.60 欧元。泊松回归分析显示,合并症数量与每一种医疗保健服务的利用之间存在独立关联。
这些基于真实世界数据的结果提供了证据,表明与 OLD 患者合并症相关的护理负担独立于并超出了与 OLD 本身相关的负担,并且强烈依赖于合并症的数量,这表明对合并 OLD 的多病患者采取整体方法是最合理的公共卫生策略。