Overexpression of LncRNA Were Suitable for Oncolytic Adenoviruse H101 Therapy in Oral Squamous-Cell Carcinoma.

BACKGROUND

As the most prevalent type of head and neck cancer, oral squamous-cell carcinoma (OSCC) accounts for nearly 90% of all oral cancer cases. Despite great progress having been made in the diagnosis and treatment of OSCC recently, the survival rate of OSCC patients has not risen remarkably. Chemotherapy is commonly used for OSCC treatment; however, the emergence of chemoresistance limits its long-term curative effect. Therefore, identifying effective biomarkers and molecular mechanisms is essential to the development of therapeutic strategies for OSCC.

METHODS

qRT-PCR assays were performed to detect expression in OSCC tissue and cells, and CCK8 assays and animal experiments used to examine cell proliferation. In addition, CCK8 assays were used to detect IC values of cisplatin, 5Fu, Dox, and oncolytic adenovirus H101.

RESULTS

We found that was overexpressed in OSCC tissue and cells and was associated with OSCC progression. In addition, knockdown of suppressed cell proliferation in vitro and in vivo. Importantly, we found that oncolytic adenovirus H101 showed better antitumor effects in OSCC with high expression, and chemotherapy showed worse anti-tumor effects in OSCC with high expression.

CONCLUSION

can act as a diagnostic biomarker for OSCC, and may be a biomarker for treatment options.