Department of Anatomy, School of Medicine, China Medical University, Taichung 404333, Taiwan.
Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan.
Int J Mol Sci. 2022 Mar 15;23(6):3142. doi: 10.3390/ijms23063142.
Ferroptosis is a newly identified mode of programmed cell death characterized by iron-associated accumulation of lipid peroxides. Emerging research on ferroptosis has suggested its implication in tumorigenesis and stemness of cancer. On the other hand, non-coding RNAs have been shown to play a pivotal role in the modulation of various genes that affect the progression of cancer cells and ferroptosis. In this review, we summarize recent advances in the theoretical modeling of ferroptosis and its relationship between non-coding RNAs and head and neck cancers. Aside from the significance of ferroptosis-related non-coding RNAs in prognostic relevance, we also review how these non-coding RNAs participate in the regulation of iron, lipid metabolism, and reactive oxygen species accumulation. We aim to provide a thorough grounding in the function of ferroptosis-related non-coding RNAs based on current knowledge in an effort to develop effective therapeutic strategies for head and neck cancers.
铁死亡是一种新发现的程序性细胞死亡模式，其特征是铁相关的脂质过氧化物积累。铁死亡的新兴研究表明其与肿瘤发生和癌症干性有关。另一方面，非编码 RNA 已被证明在调节各种基因中发挥关键作用，这些基因影响癌细胞的进展和铁死亡。在这篇综述中，我们总结了铁死亡的理论模型及其与非编码 RNA 和头颈部癌症之间关系的最新进展。除了铁死亡相关非编码 RNA 在预后相关性方面的重要性外，我们还回顾了这些非编码 RNA 如何参与铁、脂质代谢和活性氧积累的调节。我们旨在根据目前的知识，对头颈部癌症中铁死亡相关非编码 RNA 的功能进行全面的阐述，以开发有效的治疗策略。
