Jin Shuxun, Xu Chaoyang, Wang Linbo, Wei Jiangguo, Wang Songxiang
Department of Breast and Thyroid Surgery, Affiliated Jiunhua Hospital, Zhejiang University School of Medicine, Jiunhua, Zhejiang 321000, P.R. China.
Department of Breast and Thyroid Surgery, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang 312000, P.R. China.
Oncol Lett. 2021 Feb;21(2):97. doi: 10.3892/ol.2020.12358. Epub 2020 Dec 7.
Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameters of papillary thyroid carcinoma (PTC). Accordingly, the clinical data and diagnostic results from 237 patients with PTC were collected. Immunohistochemical staining was performed to evaluate the Lin28 expression levels in thyroid tissue samples. Associations between the expression levels and clinicopathological parameters were evaluated. Lin28 was expressed in 96/237 (40.5%) of PTC specimens. Compared with patients with no Lin28 expression, patients with expression had higher rates of lymph node metastasis (P<0.001) and larger tumors (P=0.011). Multivariate analysis revealed that Lin28 was associated with lymph node metastasis. Next, bioinformatics analysis was performed based using the Gene Expression Omnibus database and The Cancer Genome Atlas database. Lin28 expression was associated with aggressive tumor characteristics, such as lymph node metastasis and larger tumors. In conclusion, the present study revealed that Lin28 expression served as a risk factor for lymph node metastasis. Accordingly, Lin28 expression may be used as a prognostic marker to predict lymph node metastasis in patients with PTC. In addition, Lin28 may serve as a therapeutic target in the management of this tumor type, which may help improve patient outcomes.
Lin28参与多种类型肿瘤的进展。从临床试验收集的数据表明，Lin28的表达与甲状腺癌的预后不良相关。本研究旨在探讨Lin28表达与甲状腺乳头状癌（PTC）临床病理参数之间的关联。因此，收集了237例PTC患者的临床资料和诊断结果。采用免疫组织化学染色评估甲状腺组织样本中Lin28的表达水平。评估表达水平与临床病理参数之间的关联。Lin28在96/237（40.5%）的PTC标本中表达。与无Lin28表达的患者相比，有表达的患者淋巴结转移率更高（P<0.001）且肿瘤更大（P=0.011）。多因素分析显示Lin28与淋巴结转移有关。接下来，基于基因表达综合数据库和癌症基因组图谱数据库进行生物信息学分析。Lin28表达与侵袭性肿瘤特征相关，如淋巴结转移和肿瘤较大。总之，本研究表明Lin28表达是淋巴结转移的危险因素。因此，Lin28表达可作为预测PTC患者淋巴结转移的预后标志物。此外，Lin28可能作为这种肿瘤类型治疗的靶点，这可能有助于改善患者预后。
