The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, People's Republic of China.
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, People's Republic of China.
Oral Oncol. 2019 Nov;98:92-95. doi: 10.1016/j.oraloncology.2019.09.024. Epub 2019 Sep 28.
Lin28, a highly conserved RNA-binding protein, plays an important role in differentiation, metabolism, proliferation, pluripotency, and tumourigenicity. Lin28 overexpression promotes tumour-cell proliferation and metastasis in various human cancers, including head and neck cancer. Multiple studies demonstrate that Lin28 critically contributes to anti-tumour immunity and production of cancer stem cells in head and neck squamous cell carcinoma (HNSCC). Thus, Lin28 has potential application in HNSCC treatment.
Lin28 是一种高度保守的 RNA 结合蛋白，在分化、代谢、增殖、多能性和致瘤性中发挥重要作用。Lin28 过表达促进多种人类癌症（包括头颈部癌症）中的肿瘤细胞增殖和转移。多项研究表明，Lin28 对头颈部鳞状细胞癌（HNSCC）中的抗肿瘤免疫和癌症干细胞的产生有重要贡献。因此，Lin28 在 HNSCC 治疗中有潜在的应用。
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