Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi, China.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510220 Guangdong, China.
Dis Markers. 2020 Dec 9;2020:4565379. doi: 10.1155/2020/4565379. eCollection 2020.
The prognostic value of a new scoring system, termed F-NLR, that combines pretreatment fibrinogen level with neutrophil-lymphocyte ratio has been evaluated in various cancers. However, the results are controversial. The purpose of this study was to comprehensively analyze the prognostic value of F-NLR score in patients with cancers.
An integrated search of relevant studies was conducted by screening the PubMed and Embase databases. Pooled hazard ratios, with 95% confidence intervals (CIs), for overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS) were calculated to estimate the prognostic significance of F-NLR score in patients with various tumors. A random effects model was used for comprehensive analysis, and subgroup and meta-regression analyses were used to explore sources of heterogeneity.
Thirteen articles reporting data from of 4747 patients were included in the study. Pooled analysis revealed that high F-NLR score was significantly associated with poor OS (HR = 1.77; 95% CI, 1.51-2.08) and poor DFS/PFS (HR = 1.63; 95% CI, 1.30-2.05). Subgroup and meta-regression analyses did not alter the prognostic role of F-NLR score in OS and DFS/PFS.
Increased F-NLR score is significantly associated with poor prognosis in patients with cancers and can serve as an effective prognostic indicator.
一种新的评分系统，称为 F-NLR，它结合了预处理纤维蛋白原水平和中性粒细胞-淋巴细胞比值，已在各种癌症中评估了其预后价值。然而，结果存在争议。本研究的目的是综合分析 F-NLR 评分在癌症患者中的预后价值。
通过筛选 PubMed 和 Embase 数据库进行综合检索。计算总生存率（OS）和无病生存率（DFS）/无进展生存率（PFS）的合并风险比（HR）及其 95%置信区间（CI），以评估 F-NLR 评分在各种肿瘤患者中的预后意义。采用随机效应模型进行综合分析，并进行亚组和荟萃回归分析以探讨异质性的来源。
纳入了 13 项报告了 4747 例患者数据的研究。荟萃分析表明，高 F-NLR 评分与较差的 OS（HR=1.77；95%CI，1.51-2.08）和较差的 DFS/PFS（HR=1.63；95%CI，1.30-2.05）显著相关。亚组和荟萃回归分析并未改变 F-NLR 评分在 OS 和 DFS/PFS 中的预后作用。
F-NLR 评分升高与癌症患者的预后不良显著相关，可作为有效的预后指标。
