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瞬时受体电位香草酸亚型 2（TRPV2）：一种癌症生物标志物和潜在治疗靶点。

TRPV2: A Cancer Biomarker and Potential Therapeutic Target.

机构信息

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.

Public Health Department, Ministry of Public Health, Doha, Qatar.

出版信息

Dis Markers. 2020 Dec 10;2020:8892312. doi: 10.1155/2020/8892312. eCollection 2020.

DOI:10.1155/2020/8892312
PMID:33376561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7746447/
Abstract

The Transient Receptor Potential Vanilloid type-2 (TRPV2) channel exhibits oncogenicity in different types of cancers. TRPV2 is implicated in signaling pathways that mediate cell survival, proliferation, and metastasis. In leukemia and bladder cancer, the oncogenic activity of TRPV2 was linked to alteration of its expression profile. In multiple myeloma patients, TRPV2 overexpression correlated with bone tissue damage and poor prognosis. In prostate cancer, TRPV2 overexpression was associated with the castration-resistant phenotype and metastasis. Loss or inactivation of TRPV2 promoted glioblastoma cell proliferation and increased resistance to CD95-induced apoptotic cell death. TRPV2 overexpression was associated with high relapse-free survival in triple-negative breast cancer, whereas the opposite was found in patients with esophageal squamous cell carcinoma or gastric cancer. Another link was found between TRPV2 expression and either drug-induced cytotoxicity or stemness of liver cancer. Overall, these findings validate TRPV2 as a prime candidate for cancer biomarker and future therapeutic target.

摘要

瞬时受体电位香草酸型 2（TRPV2）通道在不同类型的癌症中表现出致癌性。TRPV2 参与介导细胞存活、增殖和转移的信号通路。在白血病和膀胱癌中，TRPV2 的致癌活性与其表达谱的改变有关。在多发性骨髓瘤患者中，TRPV2 过表达与骨组织损伤和预后不良相关。在前列腺癌中，TRPV2 过表达与去势抵抗表型和转移相关。TRPV2 的缺失或失活促进了神经胶质瘤细胞的增殖，并增加了对 CD95 诱导的细胞凋亡的抵抗。TRPV2 过表达与三阴性乳腺癌的无复发生存率高相关，而在食管鳞状细胞癌或胃癌患者中则相反。TRPV2 表达与肝癌的药物诱导细胞毒性或干性之间也存在联系。总的来说，这些发现验证了 TRPV2 作为癌症生物标志物和未来治疗靶点的主要候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e86/7746447/4eca42deeb6d/DM2020-8892312.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e86/7746447/9927c49b0478/DM2020-8892312.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e86/7746447/81d9471b299f/DM2020-8892312.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e86/7746447/4eca42deeb6d/DM2020-8892312.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e86/7746447/9927c49b0478/DM2020-8892312.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e86/7746447/81d9471b299f/DM2020-8892312.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e86/7746447/4eca42deeb6d/DM2020-8892312.003.jpg

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