Mbey Pitchou Mukaz, Mukuku Olivier, Arung Willy Kalau, Tengu Guylain Kitoko, Amisi Nasser Lubosha, Kyabu Véronique Kabila, Odimba Etienne Fwamba Koshe, Tshilombo François Katombe
Department of Surgery, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo.
Institut Supérieur des Techniques Médicales, Lubumbashi, Democratic Republic of the Congo.
Prostate Cancer. 2020 Dec 9;2020:5286929. doi: 10.1155/2020/5286929. eCollection 2020.
Prostate cancer is currently a public health problem with a frequency that varies from country to country. This study aims to describe the epidemiological, clinical, and histopathological and outcome features of prostate cancer in Lubumbashi in the Democratic Republic of Congo.
This was a descriptive longitudinal study of patients diagnosed with prostate cancer at the University Clinics of Lubumbashi. The study period was 3 years (2017 to 2019). Parameters studied were age and clinical, biological (PSA level, prostatic specific antigen), histopathological, and outcome features.
The mean age of patients was 68.7 years (range: 47 and 90 years). The 60 to 69 age group was the most affected (43.18%). Elderly subjects (≥60 years old) represented 89.77% of the cases ( = 79). Voiding disorders were the main reason for consultation in 55.68% of the cases. The mean PSA level was 133.7 ng/ml (range: 4 and 1564.5 ng/ml) at diagnosis and 125.4 ng/ml after 3 months of follow-up (range: 0.16 and 1782.1 ng/ml). Adenocarcinoma was the predominant histological type (100%). In prognosis, 31.82% of patients had a Gleason score greater than 7 and 59.10% had a high risk at the D'Amico risk classification for Prostate Cancer. Hormone therapy was administered alone in 75% of the cases and in combination with pulpectomy in 13.64% of the cases. The 3-year overall survival was 56.82%.
Prostate cancer is frequent and has a poor outcome in our country. The establishment of an individual screening policy would be an undeniable advantage in improving the prognosis.
前列腺癌目前是一个公共卫生问题，其发病率在不同国家有所不同。本研究旨在描述刚果民主共和国卢本巴希市前列腺癌的流行病学、临床、组织病理学及预后特征。
这是一项对卢本巴希大学诊所诊断为前列腺癌的患者进行的描述性纵向研究。研究期为3年（2017年至2019年）。研究参数包括年龄以及临床、生物学（PSA水平，前列腺特异性抗原）、组织病理学和预后特征。
患者的平均年龄为68.7岁（范围：47至90岁）。60至69岁年龄组受影响最大（43.18%）。老年受试者（≥60岁）占病例的89.77%（n = 79）。排尿障碍是55.68%病例的主要就诊原因。诊断时PSA平均水平为133.7 ng/ml（范围：4至1564.5 ng/ml），随访3个月后为125.4 ng/ml（范围：0.16至1782.1 ng/ml）。腺癌是主要的组织学类型（100%）。在预后方面，31.82%的患者Gleason评分大于7，59.10%的患者在前列腺癌的达米科风险分类中处于高风险。75%的病例单独进行激素治疗，13.64%的病例联合前列腺切除术。3年总生存率为56.82%。
前列腺癌在我国很常见且预后较差。制定个体化筛查政策将是改善预后的一项不可忽视的优势。
