Department of Pharmacology, University of Karachi, Karachi, Pakistan.
Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia.
Biomed Res Int. 2020 Dec 9;2020:8823038. doi: 10.1155/2020/8823038. eCollection 2020.
Dementia and related conditions disturb the ability to perform routine life activities prohibiting a person from making appropriate decisions. Seeds of and have been investigated extensively for various pharmacological properties; hence, considering the presence of bioactive compounds, it was assumed that these seed extracts may support the functioning of the central nervous system. Thus, the present study was designed to investigate the short-term and long-term memory-enhancing effects of and seed extracts in mice by the Morris water maze (spatial learning and memory), stationary rod test, and passive avoidance tests (fear-motivated tests). Ethanol extract of both seeds were prepared by standard procedure and given to animals in the doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg. The results were compared to standard drugs diazepam and imipramine given in the doses of 3 mg/kg and 30 mg/kg, respectively. Extracts of both the seeds were found to possess significant memory and cognition-enhancing effects in mice when tested by passive avoidance, stationary rod, and water maze tests. Results demonstrate memory and cognition-enhancing effects of these extracts which may be due to the presence of bioactive compounds in these seeds.
痴呆症和相关疾病会干扰执行日常活动的能力，使人无法做出适当的决策。种子已被广泛研究用于各种药理特性；因此，考虑到存在生物活性化合物，人们认为这些种子提取物可能有助于中枢神经系统的功能。因此，本研究旨在通过 Morris 水迷宫（空间学习和记忆）、固定棒试验和被动回避试验（恐惧动机试验）来研究和 种子提取物对小鼠短期和长期记忆的增强作用。通过标准程序制备两种种子的乙醇提取物，并以 50mg/kg、100mg/kg 和 200mg/kg 的剂量给予动物。将结果与分别以 3mg/kg 和 30mg/kg 给予的标准药物地西泮和丙咪嗪进行比较。当通过被动回避、固定棒和水迷宫试验测试时，两种种子的提取物均显示出对小鼠具有显著的记忆和认知增强作用。结果表明这些提取物具有记忆和认知增强作用，这可能是由于这些种子中存在生物活性化合物。
