血清可溶性 Klotho 水平升高并不能预测卒中后生存时间延长。
Higher Serum-Soluble -Klotho Level Does Not Predict Longer Survival after Stroke.
机构信息
Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.
Dialysis Center in Rybnik, Regional Specialist Hospital No. 3 in Rybnik, Rybnik, Poland.
出版信息
Biomed Res Int. 2020 Dec 7;2020:9283651. doi: 10.1155/2020/9283651. eCollection 2020.
RESULTS
There were 5 recurrent strokes and 89 deaths during the 36-month follow-up. Even though no significant differences in OS and SFS between soluble -Klotho level tertile groups were recorded, unexpectedly, OS and SFS were highest in patients with the lowest soluble -Klotho concentrations. Moreover, the Cox proportional models adjusted for established risk factors, kidney function, and the severity of stroke revealed that each 100 pg/mL increase in soluble -Klotho levels was associated with decreased OS (HR = 0.951 (0.908-0.995), < 0.05) and SFS (HR = 0.949 (0.908-0.993), < 0.05). In addition, the -Klotho to iFGF23 index was predicting neither OS nor SFS.
CONCLUSION
Soluble -Klotho levels in serum were not related to the severity of neurological deficits and long-term outcomes in patients with IS. No neuroprotective effect of soluble -Klotho levels in patients with IS was demonstrated.
结果
在 36 个月的随访期间，有 5 例复发中风和 89 例死亡。尽管可溶性-Klotho 水平三分位组之间的 OS 和 SFS 没有显著差异，但出乎意料的是，可溶性-Klotho 浓度最低的患者的 OS 和 SFS 最高。此外，调整了既定风险因素、肾功能和中风严重程度的 Cox 比例模型显示，可溶性-Klotho 水平每增加 100 pg/mL，OS（HR = 0.951（0.908-0.995），<0.05）和 SFS（HR = 0.949（0.908-0.993），<0.05）。此外，-Klotho 与 iFGF23 指数既不能预测 OS 也不能预测 SFS。
结论
血清中可溶性-Klotho 水平与 IS 患者神经功能缺损的严重程度和长期预后无关。未证明 IS 患者可溶性-Klotho 水平具有神经保护作用。
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