Department of Dermatology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Dermatol Ther. 2021 Jan;34(1):e14726. doi: 10.1111/dth.14726. Epub 2021 Jan 5.
Squaric acid dibutyl ester (SADBE) as topical immunotherapy is a good alternative in patients with refractory alopecia areata. In this study, we aimed to evaluate the effectiveness of SADBE treatment in alopecia areata (AA) and alopecia totalis/alopecia universalis (AT/AU) patients and determine the prognostic factors affecting treatment response. Data obtained from 34 (AA/AT/AU) patients treated with SADBE were analyzed retrospectively. Of the 34 patients, 16 (47.1%) were female and 18 (52.9%) were male. Sufficient responses were obtained in 19 (55.9%) patients. About 9 of the 19 patients (47.4%) with sufficient response reached a cosmetically acceptable level. As the severity of disease subsided, response to treatment increased. A better response was obtained when the disease onset in the spring and winter. Patients with a disease duration between 1 and 5 years responded better to the SADBE treatment compared to those with a disease shorter than 1 year and longer than 5 years. Severity of the disease, onset season of the disease, number of flares, duration of disease, and low levels of vitamin D in adult patients were observed to affect the SADBE response negatively.
丁基丙二酸二乙酯（SADBE）作为局部免疫疗法，是治疗难治性斑秃的一种较好的选择。在这项研究中，我们旨在评估 SADBE 治疗斑秃（AA）和全秃/普秃（AT/AU）患者的疗效，并确定影响治疗反应的预后因素。对 34 例接受 SADBE 治疗的（AA/AT/AU）患者的数据进行回顾性分析。34 例患者中，女性 16 例（47.1%），男性 18 例（52.9%）。19 例（55.9%）患者获得了充分的反应。19 例有充分反应的患者中，约有 9 例（47.4%）达到了美容可接受的水平。随着疾病严重程度的缓解，治疗反应增加。在春季和冬季发病时，治疗反应更好。与疾病病程少于 1 年和多于 5 年的患者相比，病程在 1 至 5 年的患者对 SADBE 治疗的反应更好。疾病的严重程度、疾病的发病季节、发病次数、病程以及成年患者维生素 D 水平低，均观察到对 SADBE 反应有负面影响。
