Li Yuan-Yuan, Wu Min, Liu Ming-Xi, Xie Chen-Yang, Zheng Qian, Shi Bing, Li Chen-Ghao
State Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Dec 1;38(6):657-661. doi: 10.7518/hxkq.2020.06.009.
To observe and compare the clinical efficacy of CO₂ fractional laser in the early control of scar post-secondary repair in patients with a cleft lip.
In the treatment group, 43 patients with secondary repair of cleft lip were treated via CO₂ fractional laser. The control group covered 70 patients post-cheiloplasty. The effect in the two groups after six months was compared. The duration from the beginning of the laser treatment to surgery and patient gender were analyzed to determine if they affected the efficacy of the laser treatment for scars.
CO₂ fractional laser had a definite effect on the treatment of scar post-secondary repair in patients with a cleft lip. No significant correlation was observed between treatment effect and patient gender, and no difference was noted among patients one year after surgery. In the beginning of the laser treatment, no difference was observed between the durations of <3 months and ≥3 months after the reconstruction, Therefore, early intervention of scars a year after secondary repair of a cleft lip can achieve good results.
观察并比较二氧化碳点阵激光在唇裂患者二期修复后早期控制瘢痕的临床疗效。
治疗组43例唇裂二期修复患者采用二氧化碳点阵激光治疗。对照组70例唇裂修复术后患者。比较两组治疗6个月后的效果。分析激光治疗开始至手术的时间及患者性别，以确定它们是否影响激光治疗瘢痕的疗效。
1）治疗组疗效优于对照组（P<0.000 1），治疗组总有效率为90.7%。2）男性和女性在疗效上无显著统计学差异（P=0.487）。此外，术后1年、<3个月及≥3个月病程的患者在疗效上也无显著统计学差异（P=0.055）。
二氧化碳点阵激光对唇裂患者二期修复后的瘢痕治疗有确切疗效。治疗效果与患者性别无显著相关性，术后1年患者之间无差异。在激光治疗开始时，重建后<3个月和≥3个月病程的患者之间无差异，因此，唇裂二期修复术后1年对瘢痕进行早期干预可取得良好效果。
