Ochi Harumi, Tan Lixian, Tan Wee Ping, Goh Chee Leok
*All authors are affiliated with the National Skin Centre, Singapore.
Dermatol Surg. 2017 Sep;43(9):1137-1143. doi: 10.1097/DSS.0000000000001219.
Fractional carbon dioxide (CO2) laser resurfacing unites the idea of fractional photothermolysis with an ablative 10,600-nm wavelength. This technology permits effective treatment of acne scarring, with shorter recovery and a decreased side effect profile as compared to traditional CO2 laser resurfacing.
The aims of this study were to study the efficacy and safety of fractional CO2 laser for acne scars in Asian patients.
This was a retrospective study of all patients treated with the fractional CO2 laser for facial acne scarring between January 2, 2008, and December 31, 2010, at the National Skin Centre, Singapore. Data reviewed included sex, age, and severity of acne, type of scarring, previous treatment history, frequency of treatments, adverse events, and efficacy.
Two hundred and ten fractional CO2 laser treatments for facial acne scars were performed on 107 patients (65 men and 42 women, Fitzpatrick skin Types II to V) during the study period. Sixteen of 107 patients experienced (15.0%) adverse events. The adverse events include hyperpigmentation (6.4%), blistering (4.0%), crusting (2.9%), aggravation of inflammatory acne lesions (1.7%), and scarring (0.6%). There were no reported side effects of hypopigmentation, bacterial or viral infection. Follow-up results after final laser treatment showed that 66.4% of patients reported Grade 1 skin texture improvement, that is, <25% (n = 71); 30.0% had Grade 2 improvement, that is, 25% to 50% improvement (n = 31); 3.7% had Grade 3 improvement, that is, 51% to 75% improvement (n = 4); and 0.9% had Grade 4 improvement, that is, >75% improvement (n = 1).
The study demonstrated the efficacy and safety of a fractional CO2 laser in the treatment of acne scars in Asian. Future studies are required to establish optimum treatment parameters and achieve better clinical results.
分次二氧化碳（CO₂）激光换肤术将分次光热解的理念与10600纳米的剥脱性波长相结合。与传统的CO₂激光换肤术相比，这项技术能有效治疗痤疮瘢痕，恢复时间更短，副作用也更少。
本研究旨在探讨分次CO₂激光治疗亚洲患者痤疮瘢痕的疗效和安全性。
这是一项对2008年1月2日至2010年12月31日期间在新加坡国家皮肤中心接受分次CO₂激光治疗面部痤疮瘢痕的所有患者的回顾性研究。审查的数据包括性别、年龄、痤疮严重程度、瘢痕类型、既往治疗史、治疗频率、不良事件和疗效。
在研究期间，对107例患者（65例男性和42例女性，Fitzpatrick皮肤分型为II至V型）进行了210次分次CO₂激光治疗面部痤疮瘢痕。107例患者中有16例（15.0%）出现不良事件。不良事件包括色素沉着（6.4%）、水疱形成（4.0%）、结痂（2.9%）、炎性痤疮皮损加重（1.7%）和瘢痕形成（0.6%）。未报告色素减退、细菌或病毒感染的副作用。最后一次激光治疗后的随访结果显示，66.4%的患者报告皮肤质地改善为1级，即改善<25%（n = 71）；30.0%的患者为2级改善，即改善25%至50%（n = 31）；3.7%的患者为3级改善，即改善51%至75%（n = 4）；0.9%的患者为4级改善，即改善>75%（n = 1）。
该研究证明了分次CO₂激光治疗亚洲人痤疮瘢痕的疗效和安全性。未来需要开展研究以确定最佳治疗参数并取得更好的临床效果。
