二氧化碳分次激光治疗唇裂瘢痕的最佳时机：单盲随机对照队列研究

Optimal Timing of Fractional CO 2 Laser on Cleft Lip Scars: A Single-Blind Randomized Controlled Cohort Study.

作者信息

Chi Haoshu, Zhao Xinran, Shen Lingyue, Liu Yiyun, Cai Ming

机构信息

Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Dermatol Surg. 2023 Feb 1;49(2):145-148. doi: 10.1097/DSS.0000000000003688.

DOI:10.1097/DSS.0000000000003688

PMID:36689573

Abstract

OBJECTIVE

To determine the optimal time to apply a fractional CO 2 laser for the treatment of postsecondary repair scars in patients with cleft lip.

METHODS

Forty-two patients with linear scarring after cleft lip repair were recruited from November 2021 to October 2022. A single-blind, randomized, controlled cohort study was conducted to examine the impact of fractional CO 2 laser treatment compared with conventional conservative treatment. Thirty patients started laser treatment at 1 month ( n = 10), 3 months ( n = 10), and 6 months ( n = 10) postoperatively, and 12 patients were in the control group. Each patient was treated with high-energy low-density fractional CO 2 laser treatment 3 times at an interval of 1 month. The Vancouver Scar Scale (VSS) was used for scar evaluation to determine vascularity, pigmentation, pliability, and height.

RESULTS

The VSS scores decreased significantly after laser treatment ( p < .05), with the most significant improvement in scars in the group that started treatment 1 month after the surgery.

CONCLUSION

Early postoperative fractional CO 2 laser treatment of cleft lip scars is more effective than later treatment.

摘要

目的

确定应用二氧化碳点阵激光治疗唇裂患者二期修复后瘢痕的最佳时间。

方法

于2021年11月至2022年10月招募42例唇裂修复后有线性瘢痕的患者。进行一项单盲、随机、对照队列研究，以检验与传统保守治疗相比，二氧化碳点阵激光治疗的效果。30例患者分别于术后1个月（n = 10）、3个月（n = 10）和6个月（n = 10）开始激光治疗，12例患者作为对照组。每位患者接受高能低密度二氧化碳点阵激光治疗，每月1次，共3次。采用温哥华瘢痕量表（VSS）对瘢痕进行评估，以确定血管分布、色素沉着、柔韧性和高度。