Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Ann Neurol. 2021 Mar;89(3):610-616. doi: 10.1002/ana.26004. Epub 2021 Jan 11.
There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89:610-616.
越来越多的证据表明 2019 年冠状病毒病（COVID-19）存在多种神经表现，但对于它们是否反映神经系统的结构损伤知之甚少。血清神经丝轻链（sNfL）是神经元损伤的特异性生物标志物。我们测量了 29 名危重症 COVID-19 患者、10 名危重症非 COVID-19 患者和 259 名健康对照者的 sNfL 浓度。在调整了神经合并症和年龄后，COVID-19 患者的 sNfL 浓度高于两个对照组。较高的 sNfL 水平与不良短期预后相关，表明危重症患者的神经元损伤很常见且明显。ANN NEUROL 2021;89:610-616.
