[新型冠状病毒肺炎中的急性肾损伤：基于尸检数据的临床和形态学比较]
[Acute kidney injury in COVID-19: clinical and morphological comparisons based on autopsy data].
作者信息
Kovylina M V, Astakhova O I, Zayratyants O V, Prilepskaya E A, Reshetov L V, Kolontarev K B, Pushkar D Yu
机构信息
Department of Urology of A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
Municipal clinical hospital named after S.I. Spasokukotskiy of the Moscow Healthcare Department, Moscow, Russia.
出版信息
Urologiia. 2020 Dec(6):5-10.
UNLABELLED
Severe Acute Respiratory Syndrome (SARS-CoV-2) has spread rapidly throughout the world, causing high morbidity and mortality. Analysis of clinical and autopsy data may allow to understand this disease. The results of pulmonary and renal autopsies in 37 deceased patients from COVID-19 are presented.
MATERIALS AND METHODS
An autopsy was performed in Moscow in 37 deceased patients aged from 28 to 94 years. The microscopic features of the lungs and kidneys were examined using hematoxylin and eosin staining.
RESULTS
Important findings include diffuse alveolar injury, pulmonary thrombosis and microangiopathy, as well as acute kidney injury in all cases, varying in severity.
CONCLUSIONS
We report the presence of acute kidney injury in all cases, which requires correction of renal function in patients with SARS-CoV-2, with control of serum creatinine levels, urine volume, proteinuria and hematuria.
未标注
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已在全球迅速传播，导致高发病率和死亡率。对临床和尸检数据的分析可能有助于了解这种疾病。本文展示了37例新冠病毒病死亡患者的肺和肾尸检结果。
材料与方法
在莫斯科对37例年龄在28至94岁之间的死亡患者进行了尸检。使用苏木精和伊红染色检查肺和肾的微观特征。
结果
重要发现包括弥漫性肺泡损伤、肺血栓形成和微血管病变，以及所有病例均存在的急性肾损伤，严重程度各不相同。
结论
我们报告所有病例均存在急性肾损伤，这需要对SARS-CoV-2患者的肾功能进行纠正，同时控制血清肌酐水平、尿量、蛋白尿和血尿。
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