Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark.
PLoS One. 2020 Dec 30;15(12):e0244602. doi: 10.1371/journal.pone.0244602. eCollection 2020.
To examine whether the amplitude of accommodation, the accommodative response, and the accommodative facility is affected and correlated with changes in higher-order aberrations for patients with high myopia surgically treated with small-incision lenticule extraction (SMILE).
35 highly myopic eyes (myopic spherical equivalent of at least 6 diopters) of 35 patients treated with SMILE were included. Assessments were made before and 3 months after surgery. Donders push-up-method was used to measure the amplitude of accommodation. The accommodative response was assessed using an open-field autorefractor"Grand Seiko WAM-5500" (Grand Seiko Co. Ltd., Hiroshima, Japan) in combination with a Badal optometer and stimuli of accommodation at 0.0, 0.5, 1.25, 2.0, 3.0, and 4.0 D, respectively. Accommodative facility was measured at 40 cm with ±2,00D flipper lenses. All measurements of accommodation were performed monocularly with the refractive error corrected with soft contact lenses.
The amplitude of accommodation did not change statistically significantly (mean difference -0.24 D (SD 0.98), 95% CI of mean difference -0.58 D to 0.11 D, paired-sample t(34) = -1.39; P = 0.17). The accommodative responses at 0.0, 0.5, 1.25, 2.0, 3.0, and 4.0 D did not statistically significantly change either (F(6,29) = 1.15; P = .36). Finally, the accommodative facility was also unchanged with a mean difference of 1.11 cycles per minute (SD 5.11, 95% CI of mean difference -0.64 to 2.87, paired-sample t(34) = 1.29; P = 0.21). No clinically significant associations between changes in accommodation and higher-order aberrations were found.
SMILE does not alter the amplitude of accommodation, the accommodative response, nor the accommodative facility for highly myopic patients, and the surgically induced corneal higher-order aberrations do not affect the accommodative function.
研究小切口微透镜提取术(SMILE)治疗高度近视患者的高阶像差变化与调节幅度、调节反应和调节灵活度的相关性。
纳入 35 例(35 只眼)高度近视患者(近视等效球镜度至少为 6 屈光度),行 SMILE 手术。分别于术前和术后 3 个月进行评估。采用 Donders 推近法测量调节幅度。使用 Grand Seiko WAM-5500 自动验光仪(日本广岛 Grand Seiko 公司)结合巴氏检影镜,在 0.0、0.5、1.25、2.0、3.0 和 4.0D 分别进行开放视野刺激,评估调节反应。在 40cm 处使用±2.00D 的翻转镜测量调节灵活度。所有调节测量均在软性角膜接触镜矫正屈光不正后进行单眼测量。
调节幅度的变化无统计学意义(平均差异-0.24D(标准差 0.98),95%可信区间的平均差异为-0.58D 至 0.11D,配对样本 t(34)=-1.39;P=0.17)。0.0、0.5、1.25、2.0、3.0 和 4.0D 的调节反应也无统计学意义的变化(F(6,29)=1.15;P=0.36)。最后,调节灵活度的平均值差异为 1.11 个周期/分钟(标准差 5.11,95%可信区间的平均差异为-0.64 至 2.87,配对样本 t(34)=1.29;P=0.21),也没有变化。未发现调节变化与高阶像差之间存在有临床意义的相关性。
SMILE 不会改变高度近视患者的调节幅度、调节反应和调节灵活度,手术引起的角膜高阶像差不会影响调节功能。