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高度近视小切口微透镜取出术后调节功能的变化。

Changes in accommodative function following small-incision lenticule extraction for high myopia.

机构信息

Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark.

出版信息

PLoS One. 2020 Dec 30;15(12):e0244602. doi: 10.1371/journal.pone.0244602. eCollection 2020.

Abstract

PURPOSE

To examine whether the amplitude of accommodation, the accommodative response, and the accommodative facility is affected and correlated with changes in higher-order aberrations for patients with high myopia surgically treated with small-incision lenticule extraction (SMILE).

METHODS

35 highly myopic eyes (myopic spherical equivalent of at least 6 diopters) of 35 patients treated with SMILE were included. Assessments were made before and 3 months after surgery. Donders push-up-method was used to measure the amplitude of accommodation. The accommodative response was assessed using an open-field autorefractor"Grand Seiko WAM-5500" (Grand Seiko Co. Ltd., Hiroshima, Japan) in combination with a Badal optometer and stimuli of accommodation at 0.0, 0.5, 1.25, 2.0, 3.0, and 4.0 D, respectively. Accommodative facility was measured at 40 cm with ±2,00D flipper lenses. All measurements of accommodation were performed monocularly with the refractive error corrected with soft contact lenses.

RESULTS

The amplitude of accommodation did not change statistically significantly (mean difference -0.24 D (SD 0.98), 95% CI of mean difference -0.58 D to 0.11 D, paired-sample t(34) = -1.39; P = 0.17). The accommodative responses at 0.0, 0.5, 1.25, 2.0, 3.0, and 4.0 D did not statistically significantly change either (F(6,29) = 1.15; P = .36). Finally, the accommodative facility was also unchanged with a mean difference of 1.11 cycles per minute (SD 5.11, 95% CI of mean difference -0.64 to 2.87, paired-sample t(34) = 1.29; P = 0.21). No clinically significant associations between changes in accommodation and higher-order aberrations were found.

CONCLUSIONS

SMILE does not alter the amplitude of accommodation, the accommodative response, nor the accommodative facility for highly myopic patients, and the surgically induced corneal higher-order aberrations do not affect the accommodative function.

摘要

目的

研究小切口微透镜提取术(SMILE)治疗高度近视患者的高阶像差变化与调节幅度、调节反应和调节灵活度的相关性。

方法

纳入 35 例(35 只眼)高度近视患者(近视等效球镜度至少为 6 屈光度),行 SMILE 手术。分别于术前和术后 3 个月进行评估。采用 Donders 推近法测量调节幅度。使用 Grand Seiko WAM-5500 自动验光仪(日本广岛 Grand Seiko 公司)结合巴氏检影镜,在 0.0、0.5、1.25、2.0、3.0 和 4.0D 分别进行开放视野刺激,评估调节反应。在 40cm 处使用±2.00D 的翻转镜测量调节灵活度。所有调节测量均在软性角膜接触镜矫正屈光不正后进行单眼测量。

结果

调节幅度的变化无统计学意义(平均差异-0.24D(标准差 0.98),95%可信区间的平均差异为-0.58D 至 0.11D,配对样本 t(34)=-1.39;P=0.17)。0.0、0.5、1.25、2.0、3.0 和 4.0D 的调节反应也无统计学意义的变化(F(6,29)=1.15;P=0.36)。最后,调节灵活度的平均值差异为 1.11 个周期/分钟(标准差 5.11,95%可信区间的平均差异为-0.64 至 2.87,配对样本 t(34)=1.29;P=0.21),也没有变化。未发现调节变化与高阶像差之间存在有临床意义的相关性。

结论

SMILE 不会改变高度近视患者的调节幅度、调节反应和调节灵活度,手术引起的角膜高阶像差不会影响调节功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dd0/7773189/2607b8e184d3/pone.0244602.g001.jpg

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