Angle Orthod. 2020 Jul 1;90(4):598-606. doi: 10.2319/092619-613.1.
To investigate and synthesize systematically the evidence from animal studies pertaining to the effect of pharmacological agents on tooth movement relapse following cessation of orthodontic force application.
An electronic search was conducted in seven online databases (including gray sources) without restrictions until the third week of April 2019, followed by a hand search in the reference lists of eligible articles. Controlled animal studies investigating the effect of pharmacological agents on tooth movement relapse following orthodontic treatment were selected. Relevant data were extracted from eligible studies and the risk of bias assessment was done using SYRCLE's risk of bias tool. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation tool.
The search identified 2354 records, of which 7 studies were deemed eligible for inclusion in the qualitative synthesis, with the majority presenting an unclear risk of bias. Orthodontic relapse was shown to decrease with the administration of pamidronate disodium, atorvastatin, aspirin, and chemically modified tetracycline-3. Inconsistent effects on relapse were observed after the use of simvastatin. The overall quality of retrieved evidence was assessed as low at best.
The available evidence shows that the investigated pharmacological agents may demonstrate variable effects on tooth movement relapse following cessation of orthodontic force. Additional evidence of higher quality is required to draw definitive conclusions on their effects and to make potential recommendations for clinical application.
系统调查和综合动物研究证据，了解药理学制剂在停止正畸力应用后对牙齿移动复发的影响。
电子检索了 7 个在线数据库（包括灰色来源），无时间限制，检索截至 2019 年 4 月第 3 周，随后对合格文章的参考文献进行手工检索。选择了调查药理学制剂对正畸治疗后牙齿移动复发影响的对照动物研究。从合格研究中提取相关数据，并使用 SYRCLE 的偏倚风险工具进行偏倚风险评估。使用 Grading of Recommendations Assessment, Development, and Evaluation 工具评估证据质量。
搜索共确定了 2354 条记录，其中 7 项研究被认为符合纳入定性综合分析的标准，大多数研究的偏倚风险不明确。给予帕米膦酸钠二钠、阿托伐他汀、阿司匹林和化学修饰的四环素 3 后，正畸复发减少。使用辛伐他汀后观察到对复发的影响不一致。检索到的证据整体质量评估为最低的低质量。
现有证据表明，所研究的药理学制剂在停止正畸力后对牙齿移动复发可能具有不同的影响。需要更高质量的证据来得出关于它们的影响的明确结论，并为临床应用提出潜在建议。
