Guenther W, Davous P, Godet J L, Guillibert E, Breitling D, Rondot P
Psychiatric University Hospital LDI, Munich, F.R.G.
Biol Psychiatry. 1988 Feb 1;23(3):295-311. doi: 10.1016/0006-3223(88)90040-6.
In this final electroencephalographic (EEG) mapping study of our series on motor dysfunction in neuroleptic-treated schizophrenic patients, we studied 10 right-handed patients with marked negative symptomatology [type II; raw score on the SANS (Munich version) 31.4 +/- 5.1]. Simple and multisensorimotor tasks involving both the dominant and nondominant hand were used for cortical activation. All tasks were referred to resting states obtained after specially designed relaxation procedures. In contrast to predominantly type I patients (SANS-MV score 12.3 +/- 4.9) of our previous EEG mapping studies, we found for resting states minor evidence (only) of increased power values in the frequency bands delta and theta. Furthermore, in contrast to signs of "left hemisphere dysfunction" and possible "compensatory right hemisphere overactivation" during motor tasks, which we discussed previously for our type I patients, we found for the type II schizophrenics a bilateral brain dysfunction. This consisted of "nonreactivity" in all frequency bands except alpha, in which, on the contrary, a "hyperreactivity" seemed to be present. In combination with evidence of bilateral hemispheric dysfunction in type II patients reported by other authors using EEG, evoked potentials, regional cerebral blood flow (rCBF) and magnetic resonance imaging (MRI) methods, this suggests that marked bilateral brain dysfunction may be correlated in schizophrenia with a clinical syndrome corresponding rather to the "negative pole" of the positive-negative dimension. In contrast, "left hemisphere dysfunction" and "signs of compensatory overactivation" seem to be linked more to a "positive" symptomatology. Finally, discrepancies of our EEG mapping and rCBF findings during motor activity suggest, speculatively, "uncoupling" between electrical and circulatory parameters in schizophrenia involving both hemispheres in type II, and predominantly the left hemisphere in type I, patients.
在我们关于抗精神病药物治疗的精神分裂症患者运动功能障碍系列研究的最后一项脑电图（EEG）图谱研究中，我们对10名有明显阴性症状的右利手患者进行了研究[II型；SANS（慕尼黑版）原始得分31.4±5.1]。使用涉及优势手和非优势手的简单及多感觉运动任务来激活皮层。所有任务均参照经过特殊设计的放松程序后获得的静息状态。与我们之前EEG图谱研究中主要为I型的患者（SANS - MV得分12.3±4.9）不同，我们发现静息状态下仅在δ和θ频段有轻微的功率值增加迹象。此外，与我们之前针对I型患者讨论过的运动任务期间“左半球功能障碍”迹象及可能的“代偿性右半球过度激活”不同，我们发现II型精神分裂症患者存在双侧脑功能障碍。这表现为除α频段外所有频段的“无反应性”，相反，α频段似乎存在“反应过度”。结合其他作者使用EEG、诱发电位、局部脑血流（rCBF）和磁共振成像（MRI）方法报告的II型患者双侧半球功能障碍证据，这表明精神分裂症中明显的双侧脑功能障碍可能与对应于正负维度“负极”的临床综合征相关。相比之下，“左半球功能障碍”和“代偿性过度激活迹象”似乎更多地与“阳性”症状相关。最后，我们在运动活动期间的EEG图谱和rCBF研究结果的差异推测表明，在精神分裂症中，II型患者涉及双侧半球，I型患者主要涉及左半球，电参数和循环参数之间存在“解耦”。
