Karson C N, Coppola R, Morihisa J M, Weinberger D R
Arch Gen Psychiatry. 1987 Jun;44(6):514-7. doi: 10.1001/archpsyc.1987.01800180024003.
Several topographic mapping studies of electroencephalographic (EEG) power spectra have reported increased slow (delta) activity in the frontal regions of schizophrenic patients. Using supraorbital and lateral canthus electrodes to detect eye movement, we deleted EEG epochs during eye movement in 15 medication-free patients with schizophrenia and in 13 normal control subjects. Power spectral analysis of the 28-channel EEG demonstrated a diffuse mild increase in delta activity in schizophrenic patients compared with normal control subjects but no tendency for frontal localization of this slow activity. There were no differences between schizophrenic patients and normal control subjects in other frequency bands. These results, which replicate earlier findings of increased delta activity in schizophrenia, emphasize the importance of excluding the slow activity due to eye movement in the comparisons of summed EEG spectra. This emphasis can best be ensured by equating the summed spectra from extraocular movement channels of experimental and control groups.
多项关于脑电图（EEG）功率谱的地形图研究报告称，精神分裂症患者额叶区域的慢波（δ波）活动增加。我们使用眶上电极和外眦电极检测眼动，在15名未服药的精神分裂症患者和13名正常对照受试者的眼动过程中删除了EEG时段。对28导EEG进行功率谱分析显示，与正常对照受试者相比，精神分裂症患者的δ波活动有弥漫性轻度增加，但这种慢波活动没有额叶定位倾向。精神分裂症患者与正常对照受试者在其他频段没有差异。这些结果重复了早期关于精神分裂症患者δ波活动增加的发现，强调了在比较总EEG谱时排除眼动引起的慢波活动的重要性。通过使实验组和对照组眼外肌运动通道的总谱相等，可以最好地确保这一点。
