化脓性汗腺炎和特应性皮炎：双向关联。

Hidradenitis suppurativa and atopic dermatitis: A 2-way association.

机构信息

Division of Dermatology, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Lubeck Institute of Experimental Dermatology, Lubeck, Germany.

出版信息

J Am Acad Dermatol. 2021 Dec;85(6):1473-1479. doi: 10.1016/j.jaad.2020.12.051. Epub 2020 Dec 27.

DOI:10.1016/j.jaad.2020.12.051

PMID:33378660

Abstract

BACKGROUND

The coexistence of hidradenitis suppurativa (HS) and atopic dermatitis (AD) had been reported but, to our knowledge, was not investigated in controlled studies.

OBJECTIVE

To evaluate the bidirectional association between HS and AD.

METHODS

A population-based retrospective cohort study was conducted to compare the incidence rate of AD among patients with HS (n = 6779) and age-, sex-, and ethnicity-matched control individuals (n = 33,260). Adjusted hazard ratios (HRs) and adjusted odds ratios were estimated.

RESULTS

The incidence of AD was 2.51 (95% confidence interval [CI], 2.07-3.02) and 1.24 (95% CI, 1.10-1.40) per 1000 person-years among patients with HS and control individuals, respectively. Patients with HS were twice as likely to develop AD as control individuals (HR, 2.06; 95% CI, 1.64-2.58). Furthermore, the prevalence of pre-existing AD was higher in patients with HS than in control individuals (2.5% vs 1.8%, respectively; P < .001). A history of AD was associated with a 40% increase in the odds of HS (odds ratio, 1.41; 95% CI, 1.19-1.67). Relative to patients with isolated HS, those with a dual diagnosis of HS and AD were younger and had a female predominance, lower prevalence of smoking, and lower body mass index.

LIMITATIONS

Retrospective data collection.

CONCLUSIONS

A bidirectional association between HS and AD was observed. Dermatologists should be aware of this association.

摘要

背景

化脓性汗腺炎（HS）和特应性皮炎（AD）共存的情况已有报道，但据我们所知，尚未在对照研究中进行过调查。

目的

评估 HS 和 AD 之间的双向关联。

方法

进行了一项基于人群的回顾性队列研究，比较了 HS（n=6779）患者和年龄、性别、种族匹配的对照个体（n=33260）中 AD 的发病率。估计了调整后的危险比（HR）和调整后的优势比。

结果

HS 患者和对照个体中 AD 的发病率分别为 2.51（95%置信区间[CI]，2.07-3.02）和 1.24（95% CI，1.10-1.40）/1000 人年。与对照个体相比，HS 患者发生 AD 的可能性是其两倍（HR，2.06；95% CI，1.64-2.58）。此外，HS 患者中预先存在 AD 的患病率高于对照个体（分别为 2.5%和 1.8%；P<0.001）。AD 病史与 HS 的发病几率增加 40%相关（优势比，1.41；95% CI，1.19-1.67）。与单纯 HS 患者相比，同时患有 HS 和 AD 的患者年龄更小，女性居多，吸烟率更低，体重指数更低。