Lübeck Institute of Experimental Dermatology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Immunol Res. 2021 Dec;69(6):533-540. doi: 10.1007/s12026-021-09221-4. Epub 2021 Aug 19.
Despite some common pathogenic themes, the association of hidradenitis suppurativa (HS) and rheumatoid arthritis (RA) has been poorly investigated. We aimed to evaluate the bidirectional association between HS and RA. A population-based study was conducted to compare HS patients (n = 6779) with age-, sex- and ethnicity-matched control subjects (n = 33,260) with regard to the incidence of new-onset and the prevalence of preexisting RA. Adjusted hazard ratios (HRs) and adjusted odds ratios (ORs) were estimated. The prevalence of preexisting RA was greater among patients with HS relative to controls (0.5% vs 0.3%. respectively; p = 0.019). The odds of being diagnosed with HS were 1.6-fold higher in patients with a history of RA (fully-adjusted OR, 1.66; 95% CI, 1.11-2.49; p = 0.014). The incidence rate of new-onset RA was estimated at 4.3 (95% CI, 2.5-6.8) and 2.4 (95% CI, 1.8-3.2) cases per 10,000 person-years among patients with HS and controls, respectively. The risk of RA was comparable between patients with HS and controls (fully-adjusted HR, 1.45; 95% CI, 0.77-2.72; p = 0.249). Compared to other patients with HS, those with HS and comorbid RA were older, had a higher prevalence of diabetes mellitus, hypertension, and hyperlipidemia, and had a comparable risk of all-cause mortality. In conclusions, a preexisting diagnosis of RA predisposes individuals to develop HS. Clinicians managing patients with HS and RA should be aware of this association. Further research is required to delineate the underlying pathomechanism of this observation.
尽管存在一些共同的发病机制，但化脓性汗腺炎（HS）和类风湿关节炎（RA）之间的关联尚未得到充分研究。我们旨在评估 HS 和 RA 之间的双向关联。进行了一项基于人群的研究，以比较 HS 患者（n=6779）与年龄、性别和种族匹配的对照受试者（n=33260）新发病例和预先存在的 RA 的患病率。估计了调整后的危险比（HRs）和调整后的优势比（ORs）。与对照组相比，HS 患者预先存在的 RA 患病率更高（分别为 0.5%和 0.3%；p=0.019）。有 RA 病史的患者患 HS 的可能性高 1.6 倍（完全调整后的 OR，1.66；95%CI，1.11-2.49；p=0.014）。HS 患者和对照组新发 RA 的发病率估计分别为每 10000 人年 4.3（95%CI，2.5-6.8）和 2.4（95%CI，1.8-3.2）例。HS 患者和对照组的 RA 风险相当（完全调整后的 HR，1.45；95%CI，0.77-2.72；p=0.249）。与其他 HS 患者相比，患有 HS 和合并 RA 的患者年龄更大，糖尿病、高血压和高血脂的患病率更高，全因死亡率的风险相当。总之，预先存在的 RA 诊断使个体易患 HS。管理 HS 和 RA 患者的临床医生应意识到这种关联。需要进一步研究以阐明这种观察结果的潜在发病机制。
