Khomaziuk A I, Neshcheret A P, Glebova L N, Derevianko L P, Shepelenko I V
Biull Eksp Biol Med. 1988 Jan;105(1):11-3.
Coronary arteries, coronary sinus, heart cavities, and great vessels were catheterized in anesthetized dogs with alloxan diabetes. Cardiac contractility, coronary and systemic circulation, myocardial energy metabolism and acid-base balance were studied. It was shown that the alterations of the cardiac function occurred in experimental dogs with severe diabetes mellitus. They consisted of a decrease in cardiac and working outputs, ejection period, maximum velocity of the left ventricular contractions and an increase in the projection period. These dysfunctions were caused by the alterations of the myocardial energy metabolism and systemic changes in the acid-base balance.
在使用四氧嘧啶诱导糖尿病的麻醉犬身上，对冠状动脉、冠状窦、心脏腔室和大血管进行插管。研究了心脏收缩力、冠状动脉和体循环、心肌能量代谢及酸碱平衡。结果表明，患有严重糖尿病的实验犬出现了心脏功能改变。这些改变包括心输出量和作功输出量降低、射血期缩短、左心室收缩最大速度降低以及射血前期延长。这些功能障碍是由心肌能量代谢改变和酸碱平衡的全身性变化引起的。
