Neshcheret O P, Shepelenko I V, Okhrimenko N V, Honchar I V, Khomaziuk A I
Fiziol Zh (1994). 1997;43(1-2):70-7.
On alloxane-diabetic dogs under chloralose anaesthesia without opening the chest catheterization, extracorporal perfusion and resistography of coronary arteries, catheterization and continuous drainage of coronary sinus, catheterization of major vessels and heart chambers were performed. Acute myocardial ischemia was induced by the 60 s cessation of left circumflex coronary artery extracorporal perfusion. The magnitude and peculiarity of the systemic circulation reactions during acute myocardial ischemia in dogs with moderate and mild hyperglycemia (less than 12 mmol/l), didn't differ from those in control group. But the degrees of coronary arteries dilation in the ischemic area and coronary sinus blood oxygen saturation reduction were less and the velocity of the coronary arteries resistance recovery to the base level in reperfusion period was more in these animals than in healthy dogs. In severe alloxane diabetes (hyperglycemia more than 12 mmol/l), the reflectory components of circulation reactions during myocardial ischemia, namely heart contractility function decrease, bradycardia, peripheral vessels resistance and arterial blood pressure reduction, were weakened or even absent, but the recovery velocity of cardiohaemodynamic parameters and the level of metabolic processes in myocardium was significantly slowed in the reperfusion period.
在未开胸插管的情况下，对用氯醛糖麻醉的四氧嘧啶糖尿病犬进行冠状动脉体外灌注、电阻抗描记法、冠状动脉窦插管及持续引流、主要血管和心腔插管。通过停止左旋冠状动脉体外灌注60秒诱导急性心肌缺血。中度和轻度高血糖（低于12 mmol/L）犬急性心肌缺血期间全身循环反应的程度和特点与对照组无差异。但与健康犬相比，这些动物缺血区冠状动脉扩张程度和冠状窦血氧饱和度降低程度较小，再灌注期冠状动脉阻力恢复到基础水平的速度较快。在严重的四氧嘧啶糖尿病（高血糖超过12 mmol/L）中，心肌缺血期间循环反应的反射性成分，即心脏收缩功能下降、心动过缓、外周血管阻力和动脉血压降低，减弱甚至消失，但再灌注期心脏血流动力学参数的恢复速度和心肌代谢过程水平明显减慢。
