Vasar E E, Allikmets L Kh, Soosaar A Kh
Biull Eksp Biol Med. 1988 Jan;105(1):43-5.
It has been established in experiments on male mice and rats that caerulein antagonized the behavioural effects of ketamine, an agonist of phencyclidine receptors. Caerulein (75-375 micrograms/kg) and haloperidol (0.1-1.5 mg/kg) suppressed the stereotyped behaviour and motor excitation induced by ketamine (30 mg/kg) in mice. Caerulein and haloperidol failed to affect ketamine-induced ataxia. Caerulein (10 micrograms/kg) and the opioid antagonist naloxone (5 mg/kg) completely blocked the amnestic action of ketamine (30 mg/kg) in passive avoidance experiments on rats. It seems likely that the suppression of the behavioural effects of ketamine by caerulein is related to its functional antagonism with dopamine and opioid receptors.
在对雄性小鼠和大鼠进行的实验中已证实，蛙皮素可拮抗苯环己哌啶受体激动剂氯胺酮的行为效应。蛙皮素（75 - 375微克/千克）和氟哌啶醇（0.1 - 1.5毫克/千克）可抑制氯胺酮（30毫克/千克）诱导的小鼠刻板行为和运动兴奋。蛙皮素和氟哌啶醇对氯胺酮诱导的共济失调没有影响。在对大鼠进行的被动回避实验中，蛙皮素（10微克/千克）和阿片类拮抗剂纳洛酮（5毫克/千克）完全阻断了氯胺酮（30毫克/千克）的遗忘作用。蛙皮素对氯胺酮行为效应的抑制作用似乎与其对多巴胺和阿片类受体的功能拮抗作用有关。
