Vasar E E, Allikmets L Kh, Ryzhov I V, Prakh'e I B, Soosaar A Kh
Biull Eksp Biol Med. 1988 Feb;105(2):168-71.
It has been shown in the behavioural experiments that combined pretreatment with haloperidol (0.25 mg/kg) and caerulein (40 micrograms/kg), and to a lesser extent pretreatment with caerulein alone caused long-term reversal of amphetamine (2 mg/kg) induced hyperexcitability in rats. Administration of proglumide (50 mg/kg), an antagonist of CCK-8 receptors, did not reverse long-term antiamphetamine effect of caerulein. In mice pretreatment with caerulein (50 and 100 micrograms/kg) alone or in combination with haloperidol (0.25 mg/kg) caused hypersensitivity to the behavioural effect of amphetamine (3 mg/kg). Intraventricular (I ng), but not systemic (100-500 micrograms/kg) administration of caerulein selectively antagonized seizures in mice induced by intraventricular administration of quinolinic acid (5 micrograms) and N-methyl-D-aspartate (0.2 microgram). Pretreatment with proglumide (50 mg/kg) reversed the anticonvulsive effect of caerulein in mice. In rats, caerulein failed to affect the seizures caused by intraventricular administration of quinolinic acid. The results of the present study demonstrate the existence of obvious interspecies differences in the behavioural effects of caerulein, the agonist of CCK-8 receptors, in mice and rats.
行为实验表明，联合使用氟哌啶醇（0.25mg/kg）和蛙皮素（40μg/kg）进行预处理，以及单独使用蛙皮素进行预处理（程度较轻），均可导致大鼠对苯丙胺（2mg/kg）诱导的过度兴奋产生长期逆转。给予CCK-8受体拮抗剂丙谷胺（50mg/kg），并未逆转蛙皮素对苯丙胺的长期拮抗作用。在小鼠中，单独使用蛙皮素（50和100μg/kg）或与氟哌啶醇（0.25mg/kg）联合进行预处理，会导致小鼠对苯丙胺（3mg/kg）的行为效应产生超敏反应。脑室内注射（1ng）而不是全身注射（100-500μg/kg）蛙皮素，可选择性拮抗脑室内注射喹啉酸（5μg）和N-甲基-D-天冬氨酸（0.2μg）诱导的小鼠癫痫发作。丙谷胺（50mg/kg）预处理可逆转蛙皮素对小鼠的抗惊厥作用。在大鼠中，蛙皮素未能影响脑室内注射喹啉酸引起的癫痫发作。本研究结果表明，CCK-8受体激动剂蛙皮素在小鼠和大鼠中的行为效应存在明显的种间差异。
