Vasar E E, Allikmets L Kh, Soosaar A Kh, Lang A E
Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Jul-Aug;37(4):696-702.
In experiments on male mice and rats, long-term haloperidol administration (0.25 mg/kg twice a day during 15 days) significantly changed behavioural effects of caerulein, an agonist of CCK-8 receptors. As a rule, the effects of caerulein were reduced or inverted; only long-term antagonism with amphetamine motor excitation in rats increased after the cessation of haloperidol administration. The decrease or inversion of caerulein's effects was connected with reduction of high-affinity dopamine2- and low-affinity CCK-8 receptors' density, reflecting the inhibition of some interneurons' activity in subcortical forebrain structures after haloperidol treatment. A more pronounced inhibition of dopamine's release by caerulein was the reason for the increased antiamphetamine action after long-term haloperidol treatment. It seems possible that both above mechanisms are involved in the antipsychotic action of haloperidol.
在对雄性小鼠和大鼠的实验中，长期给予氟哌啶醇（每天两次，每次0.25毫克/千克，持续15天）显著改变了胆囊收缩素八肽（CCK - 8）受体激动剂蛙皮素的行为效应。通常情况下，蛙皮素的效应会降低或反转；只有在停止给予氟哌啶醇后，大鼠中与苯丙胺运动兴奋的长期拮抗作用增强。蛙皮素效应的降低或反转与高亲和力多巴胺2受体和低亲和力CCK - 8受体密度的降低有关，这反映了氟哌啶醇治疗后皮质下前脑结构中一些中间神经元活动的抑制。长期给予氟哌啶醇治疗后，蛙皮素对多巴胺释放的更明显抑制是抗苯丙胺作用增强的原因。氟哌啶醇的抗精神病作用似乎可能涉及上述两种机制。
