Liamtsev V T, Arbuzov A A, Shakirova G Sh
Biull Eksp Biol Med. 1988 Jan;105(1):94-7.
The effect of acute pressure chamber hypoxia on the surfactant system and respiratory segment structure of the lungs were studied in rats by physical, fluorescent microscopic and morphometric methods. Acute hypoxia decreases surface activity, induces changes in cellular and extracellular surfactant fluorescence and causes the development of diffuse vesicular emphysema. On the first day of adaptation atelectatic foci dominate over emphysema, and the pulmonary structure normalizes afterwards. During de-adaptation, surface activity and cellular surfactant fluorescence are higher than the control levels. Surface activity and extracellular surfactant fluorescence recover steadily by the fifth day of adaptation. The amount of phagocytized surfactant in alveolar macrophages is increased, with the changes being opposite to those characteristic of extracellular surfactant.
采用物理、荧光显微镜及形态计量学方法，研究急性压力舱缺氧对大鼠肺表面活性物质系统及呼吸段结构的影响。急性缺氧会降低表面活性，引起细胞内和细胞外表面活性物质荧光变化，并导致弥漫性肺泡气肿的发生。在适应的第一天，肺不张灶比气肿更占优势，随后肺结构恢复正常。在去适应过程中，表面活性和细胞表面活性物质荧光高于对照水平。到适应的第五天，表面活性和细胞外表面活性物质荧光稳步恢复。肺泡巨噬细胞中吞噬的表面活性物质数量增加，其变化与细胞外表面活性物质的特征变化相反。
