Liamtsev V G, Arbuzov A A
Biull Eksp Biol Med. 1981 Nov;92(11):612-4.
It was shown in rat experiments made with the use of a complex of physical and histological methods and qualitative analysis that changes in the pulmonary surfactant system (PSS) during exposure to altitude chamber hypoxia depend on its duration and intensity. The preliminal effect of hypoxia determines the decrease in PSS activity. The increase in PSS activity seems to be the "emergency compensation" that develops in response to the action of the extreme threshold stimulus. PSS activation is related to the structural changes in pulmonary lipids. An abrupt lowering of PSS activity should be treated as the "compensation disturbance" under the effect of the postliminal stimulus. The PSS and pulmonary structure change synchronously under hypoxia.
通过运用物理和组织学方法以及定性分析的大鼠实验表明，暴露于高原舱低氧环境期间肺表面活性物质系统（PSS）的变化取决于其持续时间和强度。低氧的初始效应决定了PSS活性的降低。PSS活性的增加似乎是对极端阈值刺激作用产生的“应急补偿”。PSS的激活与肺脂质的结构变化有关。PSS活性的突然降低应被视为阈后刺激作用下的“补偿紊乱”。在低氧环境下，PSS和肺结构同步变化。
